AI Article Synopsis
- The study focuses on the relationship between glucose fluctuations and malnutrition in patients who underwent gastrectomy for gastric cancer, specifically examining the impact of these fluctuations on malnutrition as classified by the GLIM criteria.
- Data from 69 patients were analyzed over a period of one year post-surgery, revealing significant rates of severe and moderate malnutrition.
- Results indicated that severely malnourished patients experienced higher instances of hypoglycemia, particularly at night, suggesting that preventing nocturnal hypoglycemia may help improve nutritional outcomes after surgery.
Article Abstract
Purpose: The Global Leader Initiative on Malnutrition (GLIM) criteria were developed in 2018 as a global indicator of malnutrition, and the term 'malnutrition-sarcopenia syndrome' was established. Recently, it has been reported that fluctuations in blood glucose are related to sarcopenia. In this study, we investigated the effects of glucose fluctuations on malnutrition after gastrectomy using a continuous glucose monitoring (CGM) device.
Methods: We analyzed the data of 69 patients with gastric cancer (GC) who underwent curative gastrectomy between November 2017 and December 2020. CGM was performed over a 2-week period at 1 month and 1 year after surgery. The GLIM criteria included weight loss, the body mass index (BMI), and the psoas muscle mass index (PMI).
Results: One year after surgery, 25 and 35 patients had severe and moderate malnutrition, respectively. The time below range (TBR) (percent of time the glucose concentration was < 70 mg/dL) and nocturnal (00:00-06:00) TBR were significantly higher in the severe malnutrition group than in the other groups (TBR: normal/moderate 17.9% vs. severe 21.6%, P = 0.039, nocturnal TBR; normal/moderate 30.6% vs. severe 41.1%, P = 0.034).
Conclusions: Post-gastrectomy hypoglycemia, including long nocturnal hypoglycemia, was higher in severely malnourished patients than in other patients even 1 year after surgery. Prevention of nocturnal hypoglycemia may be the key to improving malnutrition following gastrectomy.
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| http://dx.doi.org/10.1007/s00595-024-02799-w | DOI Listing |
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