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Advanced Management of Complex Transplant Lithiasis: Low Lithotomy and Boot Stirrups Technique.
Am J Case Rep
January 2025
Department of Urology, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China.
BACKGROUND Transplant lithiasis may be rare but poses significant risk to the renal graft function of the recipient. Immediate management is necessitated upon first detection, to prevent further complications. CASE REPORT We report 2 cases of transplant lithiasis that were not treated immediately upon first detection.
View Article and Find Full Text PDFA novel histologic index for polyomavirus nephropathy in comparison with the Banff scoring system: Clinical validation, prognostic implication, and correlation with plasma viral load.
Ann Diagn Pathol
December 2024
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, United States - 77030.
BK Polyomavirus nephropathy (PVN) with definitive diagnosis on biopsy, presents incidentally or with varying degrees of graft dysfunction. Banff working group on PVN has proposed a novel scoring system in renal biopsies, to identify patients with higher risk of graft failure. In this study, we attempted to validate the Banff scoring system at index biopsies and correlate with a novel index score, plasma BK-virus load and graft outcome.
View Article and Find Full Text PDFBK Polyomavirus Infection in Kidney Transplantation: A Comprehensive Review of Current Challenges and Future Directions.
Int J Mol Sci
November 2024
Kidney Transplant Department, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, 75010 Paris, France.
BK polyomavirus (BKPyV) infection of the kidney graft remains a major clinical issue in the field of organ transplantation. Risk factors for BKPyV-associated nephropathy (BKPyVAN) and molecular tools for determining viral DNA loads are now better defined. BKPyV DNAemia in plasma, in particular, plays a central role in diagnosing active infection and managing treatment decisions.
View Article and Find Full Text PDFRecent advances in discovery and functional analysis of the small proteins and microRNA expressed by polyomaviruses.
Virology
January 2025
Lewis Katz School of Medicine at Temple University, Department of Microbiology, Immunology and Inflammation Center for Neurovirology and Gene Editing, 3500 N. Broad Street, Philadelphia, PA, 19140, USA. Electronic address:
Article Synopsis
- * Some polyomaviruses can cause serious diseases such as polyomavirus-associated nephropathy, progressive multifocal leukoencephalopathy, trichodysplasia spinulosa, and Merkel cell carcinoma.
- * Recent research focuses on the functions of viral proteins and microRNA that these viruses express, shedding light on their role in viral biology, how they transform cells, and their potential impact on disease progression.
Serum and urine nucleic acid screening tests for BK polyomavirus-associated nephropathy in kidney and kidney-pancreas transplant recipients.
Cochrane Database Syst Rev
November 2024
Sydney School of Public Health, University of Sydney, Sydney, Australia.
Background: BK polyomavirus-associated nephropathy (BKPyVAN) occurs when BK polyomavirus (BKPyV) affects a transplanted kidney, leading to an initial injury characterised by cytopathic damage, inflammation, and fibrosis. BKPyVAN may cause permanent loss of graft function and premature graft loss. Early detection gives clinicians an opportunity to intervene by timely reduction in immunosuppression to reduce adverse graft outcomes.
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