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Post-genomic illumination of paclitaxel biosynthesis.
Nat Plants
December 2024
Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Article Synopsis
- * Currently, paclitaxel is produced through a semi-synthesis process, using a compound called baccatin III extracted from Taxus plants, although many biosynthesis intermediates remain unknown.
- * Recent genomic studies have identified key genes for baccatin III and paclitaxel biosynthesis, which could lead to advancements in understanding the full biosynthetic pathway and improving industrial production through synthetic biology, despite ongoing significant challenges.
Uncovering the baccatin III biosynthetic pathway for sustainable taxoid supply.
Sci Bull (Beijing)
May 2024
State Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address:
Characterization and heterologous reconstitution of biosynthetic enzymes leading to baccatin III.
Science
February 2024
Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.
Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of a highly functionalized diterpenoid core skeleton (baccatin III) and the subsequent assembly of a phenylisoserinoyl side chain. Despite intensive investigation for half a century, the complete biosynthetic pathway of baccatin III remains unknown.
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