Precocious puberty has traditionally been defined as the onset of secondary sexual characteristics occurring before age 8 years in girls and 9 years in boys. This earlier onset of puberty may have significant physical and psychological consequences if left untreated. Moreover, it should be excluded that pubertal signs are not secondary to malignancies, other organic aetiologies or associated syndromic phenotypes. Initial assessment involves a thorough medical history and physical examination; a hand and wrist X-ray to determine bone age, and hormonal tests might be indicated to confirm the diagnosis and to determine the origin of hormonal production. Treatment options depend on the underlying cause. Given the complexity of the differential diagnosis, this article aims to familiarise clinicians with the different steps that can be taken when precocious puberty is suspected.
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| http://dx.doi.org/10.1136/archdischild-2023-326217 | DOI Listing |
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Assessing the Diagnostic Performance of Automated Pituitary Gland Volume Measurement for Idiopathic Central Precocious Puberty.
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It is known that the pituitary gland volume (PV) in idiopathic central precocious puberty (IPP) is significantly higher than in healthy children. However, most PV measurements rely on manual quantitative methods, which are time-consuming and labor-intensive. This study aimed to automatically measure the PV of patients with IPP using artificial intelligence to accurately quantify the correlation between IPP and PV, and to improve the efficiency of diagnosing IPP.
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Second Ward of Endocrinology Department, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000.
Central precocious puberty (CPP) is an endocrine disorder in children caused by the early activation of the hypothalamic-pituitary-gonadal axis (HPGA), leading to elevated gonadotropin-releasing hormone (GnRH), which triggers the development of gonads and the secretion of sex hormones. This eventually results in the development of internal and external genitalia and secondary sexual characteristics. CPP significantly affects the physical and mental health of children and may increase the risk of various adult diseases.
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