AI Article Synopsis
- Several treatments for Demodex blepharitis exist, but they often have undesirable side effects; lotilaner is proposed as a safer alternative.
- A systematic review and meta-analysis, analyzing six relevant studies, determined lotilaner's effectiveness in eradicating Demodex mites.
- Results indicate that lotilaner is not only effective but also well-tolerated, suggesting it could be a promising treatment option for Demodex blepharitis, and consideration of cost-effectiveness is encouraged.
Article Abstract
Purpose: Several treatments have been in use for Demodex blepharitis, before the discovery of lotilaner, like tea tree oil and antibiotics; however, they either have irritable effects or systemic adverse effects, respectively. Lotilaner, a novel ectoparasiticide, has been proposed as a treatment for patients grappling with Demodex blepharitis. This review aims to assess the safety and efficacy of lotilaner in the treatment of Demodex blepharitis.
Design: Systematic review and meta-analysis.
Methods: An extensive search was conducted on PubMed, Cochrane Library, Scopus, and Google Scholar to find relevant literature till July 31, 2023 following the PRISMA guidelines. A total of 143 articles were retrieved by database searching, out of which 6 studies met the inclusion criteria and were included in the review. Four randomized controlled trials were included in the meta-analysis of mite eradication incidence. The review is registered with PROSPERO: CRD42023459997.
Results: Lotilaner is effective in eradicating Demodex mites in individuals suffering from Demodex blepharitis according to RR for the intervention versus the control group of 3.55 (95% confidence interval [CI]: 2.87-4.40, P < .00001, I = 0%). The meta-analysis of clinically meaningful collarette score revealed the summary RR for the intervention versus the control group was 3.15 (95% CI: 2.56-3.89, P < 0.00001, I = 27%). In conclusion, the results of the included studies were comparable and consistent.
Conclusions: Our results indicated that lotilaner is an effective, well-tolerated, and promising drug in treating patients with Demodex blepharitis. Lotilaner administration and cost-effectiveness should now be contemplated for the study population as these constituents have a vital impact on its treatment success.
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| http://dx.doi.org/10.1016/j.ajo.2024.03.019 | DOI Listing |
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