Proton therapy has emerged as an advantageous modality for tumor radiotherapy due to its favorable physical and biological properties. However, this therapy generates induced radioactivity through nuclear reactions between the primary beam, secondary particles, and surrounding materials. This study focuses on systematically investigating the induced radioactivity in the gantry room during pencil beam scanning, utilizing both experimental measurements and Monte Carlo simulations. Results indicate that patients are the primary source of induced radioactivity, predominantly producing radionuclides such as C, N, and O. Long-term irradiation primarily generates radionuclides like Na, Na, and Mn etc. Additionally, this study estimates the individual doses received by medical workers in the gantry room, the irradiation dose for patient escorts, and the additional dose to patients from residual radiation. Finally, the study offers recommendations to minimize unnecessary irradiation doses to medical workers, patient escorts, and patients.
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http://dx.doi.org/10.1016/j.apradiso.2024.111297 | DOI Listing |
Appl Radiat Isot
January 2025
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India.
F radioactive isotope is widely used in PET imaging for nuclear medicine. Medical linear accelerators producing high-flux bremsstrahlung beams up to 20 MeV are commonly used in radiation therapy. Hence, the production of F through photon-induced channels will reduce many of the intricacies in transportation and handling.
View Article and Find Full Text PDFAnal Methods
January 2025
National Key Laboratory of Uranium Resources Exploration-Mining and Nuclear Remote Sensing, Beijing, 100029, China.
With the increasing demand for energy, nuclear energy has been developing rapidly. The quantitative detection and qualitative identification of uranium (U) are of great significance for the comprehensive and efficient use of U resources and the control of nuclear and radioactive substances. In this study, the detection of U is divided into liquid sample detection, solid sample detection, gas sample detection, and industrial detection from the perspectives of the sample state and detection environment.
View Article and Find Full Text PDFBiomarkers
January 2025
Department of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.
Background: Radon, a radioactive gas, is a significant risk factor for lung cancer, especially in non-smokers. This study examines the expression of exosomal microRNAs (miRNAs) as potential biomarkers for radon-induced effects.
Methods: A total of 109 participants from high- and low-radon areas in Kazakhstan were included.
Integr Cancer Ther
January 2025
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
Objective: To observe the clinical efficacy of Dendrobium officinale in the treatment of radiotherapy-induced oral mucositis in nasopharyngeal carcinoma patients, and to explore its regulating effect on immune function and oral microbiota by comparing immune-related factors and oral microbiota before and after the intervention.
Methods: We conducted a randomized double-blinded controlled trial in Zhejiang Cancer Hospital. Sixty patients with nasopharyngeal cancer combined with radiotherapy-induced oral mucositis were randomly divided into a study group and control group, with 30 cases in each group The study group used compound vitamin B12 solution and Dendrobium tea drink, and the control group simply used compound vitamin B12 solution rinse.
Mol Imaging Biol
January 2025
Department of Radiology, Weill Cornell Medicine, 413 E 69th Street, Room BB-1604, New York, NY, 10021, USA.
Purpose: Treatment of pediatric cancers with doxorubicin is a common and predictable cause of cardiomyopathy. Early diagnosis of treatment-induced cardiotoxicity and intervention are major determinants for the prevention of advanced disease. The onset of cardiomyopathies is often accompanied by profound changes in lipid metabolism, including an enhanced uptake of short-chain fatty acids (SCFA).
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