Background: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity.
Methods: We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity.
Results: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity ( > 0.05).
Conclusion: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.
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| http://dx.doi.org/10.1177/13524585241240406 | DOI Listing |
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