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Treatment optimisation for blood pressure with single-pill combinations in India (TOPSPIN) - Protocol design and baseline characteristics.
Int J Cardiol Cardiovasc Risk Prev
December 2024
Imperial Clinical Trials Unit, Imperial College London, 1st Floor, Stadium House, 68 Wood Lane, London, W12 7RH, UK, United Kingdom.
Background: The burden of over 300 million individuals living with hypertension in India is increasing steadily. Most current guidelines recommend initial combination therapy for effective blood pressure (BP) control. However, there is no randomised evidence to inform which combinations to use in the South Asian population, who account for over one-quarter of the world's population.
View Article and Find Full Text PDFGuideline-directed antihypertensive medication use among young adult participants with uncontrolled hypertension at enrollment in the MyHEART study.
BMC Cardiovasc Disord
November 2024
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, McConnell Hall, 1010 Mound Street, Madison, WI, 53715, USA.
Article Synopsis
- * The study analyzed data from the MyHEART trial, focusing on participants' antihypertensive medication use and categorizing them into groups based on their medication status.
- * Results showed that half of the participants were not on antihypertensives at enrollment, while among those who were, a majority used first-line medications, with variations in usage linked to factors like age, sex, and race.
Although the benefits of anti-hypertensive treatment are well known, the proportion of hypertensive patients with controlled blood pressure (BP) remains suboptimal. The present study aimed to compare BP control conditions in a hypertension-specialized clinic and non-hypertension-specialized clinics. This cross-sectional study used data from 379 treated patients who measured home BP in the Ohasama study between 2016 and 2019 (men: 43.
View Article and Find Full Text PDFThe Increasing Problem of Resistant Hypertension: We'll Manage till Help Comes!
Med Sci (Basel)
October 2024
Department of Translational Medical Sciences, Section of Cardiology, University of Campania Luigi Vanvitelli, 80131 Naples, Italy.
Arterial hypertension remains the major cardiovascular risk worldwide. It is estimated that under 50 years of age one in every three adults is hypertensive while beyond the age of 50 the prevalence is almost 50% globally. The latest World Health Organization (WHO) Global Report on Hypertension indicated that the global number of hypertensive patients almost doubled in the last three decades, with related increasing deaths, disability, and costs annually.
View Article and Find Full Text PDF[The delapril-indapamide combination in treatment of arterial hypertension: practical implications in light of the new guidelines.].
Recenti Prog Med
October 2024
Dipartimento di Cardiologia, Ospedale Santa Maria della Misericordia, Perugia.
The recent guidelines issued by the European Society of Hypertension reaffirmed that the degree of control of hypertension remains suboptimal worldwide. In order to increase the proportion of well-controlled patients, in addition to nonpharmacological measures, it is necessary to improve the implementation of drug therapy in the clinical practice as much as possible. Initial therapy should almost always be based on the combination, free or fixed, between ACE inhibitor drugs, or direct angiotensin II inhibitors ('sartans') and diuretics (thiazide or thiazide-like) or calcium channel blockers at the maximum recommended and well-tolerated dose.
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