AI Article Synopsis
- The study analyzed data from the National Health and Nutrition Examination Survey (1999-2020) to evaluate trends in blood lead levels, their association with blood pressure, and mortality rates in the US.
- Blood lead levels decreased significantly during this period, with a rise in the percentage of people having low lead levels; however, total mortality was not linked to blood lead levels.
- The research concluded that stricter environmental policies have reduced lead exposure's impact on overall mortality, but there is still a slight association with cardiovascular deaths, which is not linked through blood pressure.
Article Abstract
Objectives: We undertook time-stratified analyses of the National Health and Nutrition Examination Survey in the US to assess time trends (1999-2020) in the associations of blood lead (BL) with blood pressure, mortality, the BL-associated population attributable fraction (PAF).
Methods: Vital status of participants, 20-79 years old at enrolment, was ascertained via the National Death Index. Regressions, mediation analyses and PAF were multivariable adjusted and standardized to 2020 US Census data.
Results: In time-stratified analyses, BL decreased from 1.76 μg/dl in 1999-2004 to 0.93 μg/dl in 2017-2020, while the proportion of individuals with BL < 1 μg/dl increased from 19.2% to 63.0%. Total mortality was unrelated to BL (hazard ratio (HR) for a fourfold BL increment: 1.05 [95% confidence interval, CI: 0.93-1.17]). The HR for cardiovascular death was 1.44 (1.01-2.07) in the 1999-2000 cycle, but lost significance thereafter. BL was directly related to cardiovascular mortality, whereas the indirect BL pathway via BP was not significant. Low socioeconomic status (SES) was directly related to BL and cardiovascular mortality, but the indirect SES pathway via BL lost significance in 2007-2010. From 1999-2004 to 2017-2020, cardiovascular PAF decreased ( P < 0.001) from 7.80% (0.17-14.4%) to 2.50% (0.05-4.68%) and number of lead-attributable cardiovascular deaths from 53 878 (1167-99 253) to 7539 (160-14 108).
Conclusion: Due to implementation of strict environmental policies, lead exposure is no longer associated with total mortality, and the mildly increased cardiovascular mortality is not associated with blood lead via blood pressure in the United States.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216377 | PMC |
| http://dx.doi.org/10.1097/HJH.0000000000003713 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The effect of short-term exposure to air pollution on the admission of ischemic stroke and its interaction with meteorological factors.
Public Health
January 2025
Department of Neurology, First Affiliated Hospital of Gannan Medical Univesity, Ganzhou, 341000, Jiangxi, China. Electronic address:
Objectives: The aim of this study was to investigate the associations, potential effects, and interactions between short-term exposure to air pollution and the risk of ischemic stroke (IS).
Study Design: An ecological study.
Methods: Daily data on IS incidents, air pollution, and meteorological conditions were collected from 2017 to 2021 in Gannan.
Summer Heatwave, Ozone Pollution and Ischemic Stroke Mortality: An Individual-Level Case-Crossover Study.
Environ Res
January 2025
School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China. Electronic address:
Background: Although the association of short-term ozone and heatwave exposure with cerebrovascular disease has been well documented, it remains largely unknown whether their co-exposure could synergistically trigger ischemic stroke (IS) mortality.
Methods: We performed an individual-level, time-stratified case-crossover analysis utilizing province-wide IS deaths (n =59079) in warm seasons (May-September) during 2016-2019, across Jiangsu, eastern China. Heatwave was defined according to a combination of multiple temperature thresholds (90-97.
Extreme hot weather events and risk of hospitalisation for cardiovascular and respiratory diseases in older people in Hong Kong in 2012 to 2018.
J Gerontol A Biol Sci Med Sci
January 2025
Institute of Health Equity, Chinese University of Hong Kong, Hong Kong SAR.
Background: The older population is more vulnerable to the impact of extreme hot weather events (EHWEs), while the impact on the frailer institutionalised older population was seldom assessed. Our objective was to assess the relationship between EHWEs and hospitalisation risks among institutionalised and community-dwelling older people.
Methods: We used territory-wide hospitalisation record of Hong Kong from year 2012 to 2018 to assess the associations between EHWEs and cardiovascular and respiratory disease hospitalisations in the population aged 65 or above.
Heat-related mortality in Mexico: A multi-scale spatial analysis of extreme heat effects and municipality-level vulnerability.
Environ Int
December 2024
Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA; Irset Institut de Recherche en Santé, Environnement et Travail, UMR-S 1085, Inserm, University of Rennes, EHESP, Rennes, France.
Understanding effects of extreme heat across diverse settings is critical as social determinants play an important role in modifying heat-related risks. We apply a multi-scale analysis to understand spatial variation in the effects of heat across Mexico and explore factors that are explaining heterogeneity. Daily all-cause mortality was collected from the Mexican Secretary of Health and municipality-specific extreme heat events were estimated using population-weighted temperatures from 1998 to 2019 using Daymet and WorldPop datasets.
View Article and Find Full Text PDFAssociation between air pollution and hospitalization for acute exacerbation of kidney failure: A nationwide time-stratified case-crossover study in China.
J Hazard Mater
December 2024
Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China; National Center for Children's Health, Children's Hospital of Fudan University, Shanghai 201102, China. Electronic address:
Background: Air pollution is a potential risk factor for kidney disease; however, the impact on kidney failure exacerbation is underexplored. This study assessed the short-term effects of air pollution on hospitalization for kidney failure exacerbation.
Methods: This nationwide, time-stratified, case-crossover study included 45,249 hospitalized patients with kidney failure from 153 hospitals in 20 Chinese provinces between 2013 and 2020.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!