AI Article Synopsis
- The study investigates the relationship between postoperative radiotherapy (PORT) and overall survival (OS) in patients with early-stage HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) that has positive lymphovascular invasion (LVI).
- Researchers analyzed data from 2,768 patients treated surgically between 2010 and 2019, focusing on those with LVI and PORT to determine its impact on 5-year OS.
- Findings suggest that PORT does not significantly improve 5-year OS for patients with early-stage HPV+ OPSCC who only exhibit LVI as an adverse feature, implying that they might not need PORT after surgery.
Article Abstract
Background: Postoperative radiotherapy radiation therapy (PORT) for early-stage human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) with positive lymphovascular invasion (LVI) has an unclear association with overall survival (OS).
Methods: This retrospective cohort study queried the National Cancer Database for surgically treated, T1-2, N0-1 HPV+ OPSCC from 2010 to 2019. Primary exposures were LVI and PORT, and the main outcome was 5-year OS. Odds ratios and hazard ratios (HR) with 95% confidence intervals (CIs) were generated using multivariable models and Cox proportional hazard models, respectively.
Results: Of 2768 patients, average age was 59.3 years, 2207 (79.7%) were male, and 386 (13.9%) had LVI. Of patients with LVI as their sole adverse pathologic feature, 220 (57.0%) received PORT, which was not associated with 5-year OS (HR, 1.13; CI, 0.65-1.19).
Conclusions: Patients with surgically treated, early-stage HPV+ OPSCC and positive LVI as their only pathologic adverse feature may not require PORT.
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| http://dx.doi.org/10.1002/hed.27740 | DOI Listing |
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