AI Article Synopsis
- Ewing's sarcoma family of tumors (EWSFT) predominantly affects adolescents and requires a combination of treatment methods for better outcomes; this study analyzed patient data from 2009-2017.
- Among 173 patients, the study found that 25% presented with metastatic disease at diagnosis, and the most common tumor location was the pelvis.
- Key factors linked to poorer overall survival included larger tumor size, metastasis, and inadequate necrosis response to treatment, highlighting the need for ongoing research into better therapies in challenging environments.
Article Abstract
Unlabelled: Ewing's sarcoma family of tumors (EWSFT) is common in the second decade of life. Achieving good outcomes in EWSFT requires a multimodality approach. We report the clinico-pathological features, treatment, and survival outcomes of patients with EWSFT treated at our center. Patients diagnosed and treated for EWSFT at our center from 2009-2017 were included in this study. Data was collected from the patient's case records. Event-free survival (EFS) and overall survival (OS) were estimated using the Kaplan-Meier method. The study included 173 patients among whom 44 (25%) patients were metastatic at diagnosis. The median age of patients was 16 years. The most common site of the primary tumor was the pelvis (16.1%), followed by long bones. The median follow-up was 75 months and the 5-year EFS and OS were 43.7% and 45.1% respectively for the overall cohort whereas for the localized disease were 56.6% and 57.2% respectively. Metastatic disease, tumor volume > 200 ml, tumor diameter > 8 cm, pelvic site, hemoglobin < 10 gms%, elevated lactate dehydrogenase, positive margin, and necrosis less than 90% were significantly associated with inferior OS on univariate analysis. On multivariate analysis, metastasis disease, tumor diameter > 8 cm, and necrosis < 90% were significantly associated with inferior OS. Large tumors, advanced disease, and poor response to chemotherapy are associated with poor outcomes in EWSFT. Whether the use of dose-dense chemotherapy and/or autologous stem cell transplant would improve outcomes without increased toxicity in resource-limited settings needs to be explored.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13193-023-01817-6.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948649 | PMC |
| http://dx.doi.org/10.1007/s13193-023-01817-6 | DOI Listing |
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