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| http://dx.doi.org/10.1111/srt.13662 | DOI Listing |
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Dose reduction and discontinuation of biologic and targeted synthetic disease-modifying anti-rheumatic drugs (DMARDs) for people with psoriatic arthritis in remission or low disease activity.
Cochrane Database Syst Rev
December 2024
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To determine the benefits and harms of dose reduction or discontinuation of biologic disease-modifying anti-rheumatic drugs or targeted synthetic disease-modifying anti-rheumatic drugs in adults with psoriatic arthritis who are in remission or a low disease activity state.
View Article and Find Full Text PDFTopical Application of Dipyridamole and Roflumilast Combination Nanoparticles Loaded Nanoemulgel for the Treatment of Psoriasis in Rats.
Int J Nanomedicine
December 2024
Laboratory of Chemical, Galenic and Pharmacological Development of Medicines (LR12ES09), Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia.
Background: Phosphodiesterase-4 is an enzyme that regulates immune responses and contributes to the development of psoriasis. Dipyridamole and roflumilast function as phosphodiesterase-4 inhibitors, reducing pro-inflammatory cytokine expression. The aim was to evaluate the anti-psoriatic effect of the topical administration of dipyridamole and roflumilast nanoemulgel combination on imiquimod-induced psoriasiform skin inflammation in rats.
View Article and Find Full Text PDFIWR-1 attenuates the promotional effect of IL-36γ in a mouse model of psoriasis.
BMC Immunol
November 2024
Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan Dongcheng District, Beijing, China.
Background: Psoriasis is a chronic inflammatory skin disease. The Wnt/β-catenin signaling pathway is essential for the regulation of adult stem cells, homeostasis, and tissue regeneration; however, the relationship between this pathway and interleukin (IL)-36γ in the pathogenesis of psoriasis remains unclear.
Methods: In this study, psoriasiform model mice were established using imiquimod (IMQ) induction.
Bilayered skin equivalent mimicking psoriasis as predictive tool for preclinical treatment studies.
Commun Biol
November 2024
University Hospital Jena, Department of Dermatology, Friedrich Schiller University Jena, Jena, Germany.
Article Synopsis
- - Psoriasis is a common skin condition that currently has no cure, and more research is needed to understand its underlying processes and develop new treatments; however, there are challenges due to the lack of effective preclinical models.
- - Recent advancements include creating 3D skin models that mimic psoriasis features, allowing researchers to study treatment responses using these replicas, which exhibit characteristics like inflammation and hyperproliferation when treated with cytokines.
- - Treatments such as dexamethasone (DEX), celastrol (CEL), and biologics like adalimumab (ADM) and bimekizumab (BMM) demonstrated varying degrees of effectiveness in reducing inflammation and promoting skin differentiation, suggesting that this new in vitro
Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity.
Cell Commun Signal
November 2024
Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, 25123, Italy.
Background: The physiological relevance of cell-to-cell communication mediated by small extracellular vesicle-encapsulated microRNAs (sEV-miRNAs) remains debated because of the limiting representativity of specific miRNAs within the extracellular pool. We hypothesize that sEV-miRNA non-canonical function consisting of the stimulation of Toll-like receptor 7 (TLR7) may rely on a global shift of the sEV cargo rather than on the induction of one or few specific miRNAs. Psoriasis represents an ideal model to test such hypothesis as it is driven by overt activation of TLR7-expressing plasmacytoid dendritic cells (pDCs) following keratinocyte damage.
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