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| http://dx.doi.org/10.1186/s40779-024-00522-x | DOI Listing |
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Interactions between antidiabetes medications and heart-brain axis.
Curr Opin Endocrinol Diabetes Obes
February 2025
Department of Cardiology, National University Heart Centre, Singapore.
Purpose Of Review: The heart - brain axis (HBA) is the physiological interactions between the cardiovascular and nervous systems through autonomic nerves, hormones, and cytokines. Patients diagnosed with diabetes mellitus have an increased risk of the cardiovascular and neurological diseases. However, recent evidence demonstrated that different antidiabetic drugs may delay cognitive impairment and improve cardiovascular outcomes.
View Article and Find Full Text PDFArterial calcification in the heart-brain axis and cognitive performance over time.
Alzheimers Dement
December 2024
Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Article Synopsis
- - The study explored the relationship between arteriosclerosis, measured by arterial calcification in the heart-brain axis, and cognitive performance over time, using data from the Rotterdam Study with 2368 participants.
- - Findings showed that higher levels of arterial calcification were linked to poorer initial cognitive performance and a faster decline in cognitive abilities across multiple domains, particularly influenced by calcification in the intracranial carotid artery.
- - The results suggest that arterial calcification may drive cognitive decline through changes in blood flow before any neurovascular damage occurs, emphasizing the role of vascular health in maintaining cognitive function.
Unraveling the heart-brain axis: shared genetic mechanisms in cardiovascular diseases and Schizophrenia.
Schizophrenia (Heidelb)
November 2024
The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
The comorbidity between cardiovascular diseases (CVD) and schizophrenia (SCZ) has attracted widespread attention from researchers, with shared genetic causes potentially providing important insights into their association. This study conducted a comprehensive analysis of genetic data from 17 types of CVD and SCZ using genome-wide multi-trait association studies (GWAS), employing statistical methods such as LDSC, MTAG, LAVA, and bidirectional Mendelian randomization to explore global and local genetic correlations and identify pleiotropic single nucleotide variants (SNVs). The analysis revealed a significant genetic correlation between CVD and SCZ, identifying 842 potential pleiotropic single nucleotide variants (SNVs) and multiple associated biological pathways.
View Article and Find Full Text PDFCirculating mitochondria carrying cGAS promote endothelial Secreted group IIA phospholipase A2-mediated neuroinflammation through activating astroglial/microglial Integrin-alphavbeta3 in subfornical organ to augment central sympathetic overdrive in heart failure rats.
Int Immunopharmacol
January 2025
Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China. Electronic address:
Background: Sympathoexcitation, a manifestation of heart-brain axis dysregulation, contributes to the progression of heart failure (HF). Our recent study revealed that circulating mitochondria (C-Mito), a newly identified mediator of multi-organ communication, promote sympathoexcitation in HF by aggravating endothelial cell (EC)-derived neuroinflammation in the subfornical organ (SFO), the cardiovascular autonomic neural center. The precise molecular mechanism by which C-Mito promotes SFO-induced endothelial neuroinflammation has not been fully elucidated.
View Article and Find Full Text PDFRegulation of cardiac function by the autonomic nervous system.
Physiology (Bethesda)
November 2024
Department of Cellular and Molecular Physiology, Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.
Article Synopsis
- The autonomic nervous system is essential for managing heart function, involving both the sympathetic and parasympathetic systems, as well as sensory and intrinsic neuronal components for cardiac regulation.
- Recent research has improved our knowledge of how these systems interact and their specific roles in heart physiology, which is crucial for understanding heart health.
- The review emphasizes the emerging field of neurocardiology, focusing on how insights into autonomic dysfunction can inform treatment for common cardiovascular diseases and new neuroscience-based therapies.
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