AI Article Synopsis
- * Cells use specific proteins to stabilize these curved membranes by sensing and generating curvature.
- * The review highlights recent research on protein interactions with curved membranes and examples of essential processes, like neurotransmission and endocytosis, that depend on membrane curvature.
Article Abstract
Biological membranes are integral cellular structures that can be curved into various geometries. These curved structures are abundant in cells as they are essential for various physiological processes. However, curved membranes are inherently unstable, especially on nanometer length scales. To stabilize curved membranes, cells can utilize proteins that sense and generate membrane curvature. In this review, we summarize recent research that has advanced our understanding of interactions between proteins and curved membrane surfaces, as well as work that has expanded our ability to study curvature sensing and generation. Additionally, we look at specific examples of cellular processes that require membrane curvature, such as neurotransmission, clathrin-mediated endocytosis (CME), and organelle biogenesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11069444 | PMC |
| http://dx.doi.org/10.1016/j.tibs.2024.02.005 | DOI Listing |
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