AI Article Synopsis

  • - The study investigated how treatments for acute lymphoblastic leukemia (ALL) affect blood lipid levels in children, focusing on genetic factors related to the LpL and APOE genes.
  • - Specifically, the APOE gene polymorphism rs429358 showed significant effects on lipid profile changes and was linked to a higher risk classification for some patients.
  • - Overall, the findings suggest that lipid abnormalities in pediatric ALL patients might be influenced by their APOE genotype, hinting at a need for more research to explore its potential implications for prognosis.

Article Abstract

Background: Medications used to treat acute lymphoblastic leukemia (ALL), such as L-asparaginase, can cause blood lipid disturbances. These can also be associated with polymorphisms of the lipoprotein lipase (LpL) and apolipoprotein E (APOE) genes.

Procedure: We aimed to investigate the association between lipid profile, certain LpL and APOE gene polymorphisms (rs268, rs328, rs1801177 and rs7412, rs429358 respectively) as well as the risk subgroup in 30 pediatric patients being treated for ALL, compared with 30 pediatric ALL survivors and 30 healthy controls.

Results: The only APOE gene polymorphism with significant allelic and genotypic heterogeneity was rs429358. Further analysis of this polymorphism showed that genotype (CC, CT, or TT) was significantly associated with (1) changes in the lipid profile at the end of consolidation (total cholesterol, LDL, apo-B100, and lipoprotein a) and during re-induction (total cholesterol and apo-B100), and (2) classification in the high risk-ALL subgroup (for CC genotype/C allele presence).

Conclusions: Lipid abnormalities in children being treated for ALL may be associated with the APOE genotype, which is also possibly associated with risk stratification. Further research is needed to confirm the potential prognostic value of these findings.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140815PMC
http://dx.doi.org/10.1007/s12185-024-03748-6DOI Listing

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