AI Article Synopsis
- - Microneedles are a method for delivering drugs directly to deep tissues by puncturing the skin, helping to bypass issues like the first-pass effect and reducing pain.
- - Hydrogel microneedles are beneficial for drug delivery due to their biocompatibility, adjustable mechanical properties, and the ability to control drug release, making them versatile for various applications.
- - The oral cavity's large surface area is suitable for microneedle use, as hydrogel microneedles can effectively deliver drugs while overcoming challenges from moisture and movement to enhance therapeutic outcomes.
Article Abstract
Microneedles are a transdermal drug delivery system in which the needle punctures the epithelium to deliver the drug directly to deep tissues, thus avoiding the influence of the first-pass effect of the gastrointestinal tract and minimizing the likelihood of pain induction. Hydrogel microneedles are microneedles prepared from hydrogels that have good biocompatibility, controllable mechanical properties, and controllable drug release and can be modified to achieve environmental control of drug release in vivo. The large epithelial tissue in the oral cavity is an ideal site for drug delivery via microneedles. Hydrogel microneedles can overcome mucosal hindrances to delivering drugs to deep tissues; this prevents humidity and a highly dynamic environment in the oral cavity from influencing the efficacy of the drugs and enables them to obtain better therapeutic effects. This article analyzes the materials and advantages of common hydrogel microneedles and reviews the application of hydrogel microneedles in the oral cavity.
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| http://dx.doi.org/10.1002/bip.23573 | DOI Listing |
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