A new site-selective methodology for C-H nitration of 2-indazoles has been accomplished at the C7 position using iron(III) nitrate. This strategy enables practical access to an array of 7-nitroindazoles with broad functional group tolerance in good yields. The synthesized products have been proven as valuable synthetic intermediates by demonstrating the synthetic utility. Mechanistic investigations indicate that the reaction goes through a radical pathway.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4cc00214h | DOI Listing |
Publication Analysis
Top Keywords
nitration 2-indazoles
8
site-selective direct
4
direct nitration
4
2-indazoles easy
4
easy access
4
access 7-nitroindazoles
4
7-nitroindazoles site-selective
4
site-selective methodology
4
methodology c-h
4
c-h nitration
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!