AI Article Synopsis
- The study investigates the controversial link between blood glucose levels and cognitive function in older adults, focusing on the role of the anti-aging protein Klotho.
- Researchers analyzed data from 1,445 participants in the NHANES 2011-2014 survey, assessing cognitive function and measuring serum Klotho and blood glucose levels.
- Results indicated that higher blood glucose is linked to worse cognitive performance, with Klotho partially mediating this relationship, highlighting its potential protective effects against cognitive decline.
Article Abstract
Background: The association between blood glucose and cognition is controversial. Klotho is an anti-aging protein with neural protective effects. This study aimed to use a population-based study to disentangle the relationship between blood glucose levels and cognitive function in older adults, and to explore the role of klotho in it.
Methods: A total of 1445 eligible participants from National Health and Nutrition Examination Survey (NHANES) 2011-2014 were included in our study. Cognitive function was assessed by Digit Symbol Substitution Test (DSST) and categorized into four quartiles (Q1-Q4). General characteristics and laboratory test results including serum klotho concentration and blood glucose levels were collected. Associations of cognitive function and klotho levels with blood glucose concentrations were explored through multivariate linear regression models. Mediation models were constructed to figure out the mediating role of klotho.
Results: All three multivariate linear regression models showed a negative correlation between blood glucose and cognitive function. (Model 1, β=-0.149, 95%CI: -0.202,-0.096, p=0.001; Model 2, β=-0.116, 95%CI: -0.167,-0.065, p=0.001; Model 3, β=-0.007, 95%CI: -0.118,-0.023, p=0.003). Mediation analysis showed that klotho mediated the statistical association between blood glucose level and cognitive function with proportions (%) of 12.5.
Conclusion: Higher blood glucose levels are associated with poorer cognitive performance in non-diabetic older adults, partially mediated through lower klotho levels.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948412 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1323407 | DOI Listing |
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