AI Article Synopsis
- NAFLD and cholelithiasis are common liver-related diseases that can lead to serious health complications, raising questions about their possible link.
- Mendelian randomization was used to analyze data from large studies (Million Veteran Program and UK Biobank) to explore this potential connection.
- The findings suggest that NAFLD increases the risk of developing cholelithiasis, indicating it should be considered in future research and treatment strategies for gallbladder issues.*
Article Abstract
Background And Aims: Both nonalcoholic fatty liver disease (NAFLD) and cholelithiasis are highly prevalent hepatobiliary diseases with risk of progression into severe outcomes. Considering the close relationship between liver and gallbladder in anatomy and physiology, a potential causal relationship between NAFLD and cholelithiasis has been speculated.
Methods: Mendelian randomization (MR) was employed using genome-wide association study (GWAS) summary statistics in Million Veteran Program (MVP) for NAFLD, and statistics in UK biobank for cholelithiasis.
Results: Our results demonstrate that NAFLD has a causal effect on cholelithiasis risk (OR, 1.003; 95%CI, 1.000-1.006; = 0.03). We also performed the sensitivity analysis and heterogeneity test to ensure the accuracy of outcome and avoid the reverse causality.
Conclusion: NAFLD should be regarded as a potential pathogenic factor in pathogenesis study of cholelithiasis, and be considered in assessment and treatment of cholelithiasis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948589 | PMC |
| http://dx.doi.org/10.1002/hsr2.1987 | DOI Listing |
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