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Performance of nanoparticles for biomedical applications: The / discrepancy. | LitMetric
Nanomedicine has a great potential to revolutionize the therapeutic landscape. However, up-to-date results obtained from experiments predict the performance of nanoparticles weakly or not at all. There is a need for experiments that better resemble the reality. As a result, animal experiments can be reduced, and potent candidates will not be missed. It is important to gain a deeper knowledge about nanoparticle characteristics in physiological environment. In this context, the protein corona plays a crucial role. Its formation process including driving forces, kinetics, and influencing factors has to be explored in more detail. There exist different methods for the investigation of the protein corona and its impact on physico-chemical and biological properties of nanoparticles, which are compiled and critically reflected in this review article. The obtained information about the protein corona can be exploited to optimize nanoparticles for application. Still the translation from to remains challenging. Functional screening under physiological conditions such as in full serum, in 3D multicellular spheroids/organoids, or under flow conditions is recommended. Innovative screening using barcoded nanoparticles can simultaneously test more than hundred samples regarding biodistribution and functional delivery within a single mouse.
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