AI Article Synopsis
- Extracellular vesicles play a key role in cell communication and can transport biomolecules during various biological processes, with animal cell exosomes being explored as potential drug delivery systems despite their issues like high immunogenicity and complicated preparation.* -
- Plant-derived extracellular vesicles (PDVs) offer a promising alternative for drug delivery due to their stable properties, diverse sources, and cost-effectiveness.* -
- The review highlights the methods for collecting and characterizing PDVs, their applications in biomedicine as drug carriers, and discusses the future development and challenges associated with their use.*
Article Abstract
Extracellular vesicles can transmit intercellular information and transport biomolecules to recipient cells during various pathophysiological processes in the organism. Animal cell exosomes have been identified as potential nanodrugs delivery vehicles, yet they have some shortcomings such as high immunogenicity, high cytotoxicity, and complicated preparation procedures. In addition to exosomes, plant-derived extracellular vesicles (PDVs), which carry a variety of active substances, are another promising nano-transport vehicles emerging in recent years due to their stable physicochemical properties, wide source, and low cost. This work briefly introduces the collection and characterization of PDVs, then focuses on the application of PDVs as natural or engineered drug carriers in biomedicine, and finally discusses the development and challenges of PDVs in future applications.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949304 | PMC |
| http://dx.doi.org/10.2147/IJN.S454794 | DOI Listing |
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