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| http://dx.doi.org/10.2147/JIR.S466792 | DOI Listing |
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Serum Homer1 is a Novel Biomarker for Predicting the Clinical Outcomes of Acute Ischemic Stroke Patients [Letter].
J Inflamm Res
March 2024
Department of Neurology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Serum Homer1 is a Novel Biomarker for Predicting the Clinical Outcomes of Acute Ischemic Stroke Patients.
J Inflamm Res
February 2024
Department of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, 710032, People's Republic of China.
Purpose: We aim to explore the relationship between Homer1 and the outcomes of AIS patients at 3 months.
Patients And Methods: This prospective cohort study was conducted from May 2022 to March 2023. In this study, we investigated the association between serum Homer1 levels by enzyme-linked immunosorbent assay at admission and functional outcomes of patients at 3 months after AIS.
Clinical value and expression of Homer 1, homocysteine, S-adenosyl-l-homocysteine, fibroblast growth factors 23 in coronary heart disease.
BMC Cardiovasc Disord
May 2022
Department of Cardiology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Shiyan, 442000, Hubei, China.
Background: This study aimed to explore clinical value and expression of Homer 1, S-adenosyl-l-homocysteine (SAH), homocysteine (Hcy), fibroblast growth factors (FGF) 23 in coronary heart disease (CHD).
Methods: From March 2020 to April 2021, a total of 137 patients with CHD and 138 healthy subjects who came to our hospital for physical examination and had no cardiovascular disease were retrospectively enrolled, and they were assigned to the CHD group and the control group, respectively. Patients in the CHD group were divided into stable angina pectoris (SAP) group (n = 48), unstable angina pectoris (UAP) group (n = 46), and acute myocardial infarction (AMI) group (n = 43) according to clinical characteristics for subgroup analysis.
Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity… and Return.
Biomedicines
September 2021
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties of Excellence "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.
Binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in the nucleus accumbens (NAc). This study explores in rats the long-lasting effects of early intermittent exposure to intoxicating alcohol levels at adolescence, on: (1) the response to natural positive stimuli and inescapable stress; (2) stress-axis functionality; and (3) dopaminergic and glutamatergic neuroadaptation in the NAc. We also assess the potential effects of the non-intoxicating phytocannabinoid cannabidiol, to counteract (or reverse) the development of detrimental consequences of binge-like alcohol exposure.
View Article and Find Full Text PDFATM loss disrupts the autophagy-lysosomal pathway.
Autophagy
August 2021
Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong.
Article Synopsis
- ATM protein is associated with various organelles and is critical for neuronal function, with mutations leading to ataxia-telangiectasia (A-T), a disorder affecting multiple organs.
- Research indicates that ATM deficiency may disrupt autophagy and lysosomal processes, causing synaptic maintenance and glucose uptake issues in neurons.
- The study highlights a novel interaction between ATM and the dynein protein, affecting lysosomal transport and GLUT4 translocation, providing insights into potential therapeutic targets for A-T.
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