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Promising Response of Olaparib in Patient With Germline -Mutated Metastatic Gastric Cancer. | LitMetric

AI Article Synopsis

  • *A case study highlights a 66-year-old patient with ATM-mutated metastatic gastric cancer who showed remarkable improvement when treated with olaparib, a PARP inhibitor, alongside chemo-immunotherapy, maintaining low levels of CA 19-9 for 18 months.
  • *Despite a failed phase II trial for olaparib in gastric cancer, promising results in patients with ATM mutations suggest that further research and clinical trials could be beneficial for personalized treatment approaches in this area.

Article Abstract

Gastric cancer ranks as the fifth leading cause of global cancer incidences, exhibiting varied prevalence influenced by geographical, ethnic, and lifestyle factors, as well as infection. The gene on chromosome 11q22 is vital for genomic stability as an initiator of the DNA damage response, and mutations in this gene have been associated with various cancers. Poly ADP-ribose polymerase (PARP) inhibitors, such as olaparib, have shown efficacy in cancers with homologous recombination repair deficiencies, notably in those with ATM mutations. Here, we present a case of a 66-year-old patient with germline ATM-mutated metastatic gastric cancer with very high CA 19-9 (48 000 units/mL) who demonstrated an exceptional response to the addition of olaparib to chemo-immunotherapy and subsequent olaparib maintenance monotherapy for 12 months. CA 19-9 was maintained at low level for 18 months. Despite the failure of a phase II clinical trial on olaparib in gastric cancer (NCT01063517) to meet its primary endpoint, intriguing findings emerged in the subset of ATM-mutated patients, who exhibited notable improvements in overall survival. Our case underscores the potential clinical utility of olaparib in germline ATM-mutated gastric cancer and emphasizes the need for further exploration through larger clinical trials. Ongoing research and clinical trials are essential for optimizing the use of PARP inhibitors, identifying biomarkers, and advancing personalized treatment strategies for gastric cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10953106PMC
http://dx.doi.org/10.1177/23247096241240176DOI Listing

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