Medical image segmentation is a critical task in computer vision because of facilitating precise identification of regions of interest in medical images. This task plays an important role in disease diagnosis and treatment planning. In recent years, deep learning algorithms have exhibited remarkable performance in this domain. However, it is important to note that there are still unresolved issues, including challenges related to class imbalance and achieving higher levels of accuracy. Considering the challenges, we propose a novel approach to the semantic segmentation of medical images. In this study, a new sampling method to handle class imbalance in the medical datasets is proposed that ensures a comprehensive understanding of both abnormal tissues and background characteristics. Additionally, we propose a novel loss function inspired by exponential loss, which operates at the pixel level. To enhance segmentation performance further, we present an ensemble model comprising two UNet models with ResNet backbone. The initial model is trained on the primary dataset, while the second model is trained on the dataset obtained through our sampling method. The predictions of both models are combined using an ensemble model. We have assessed the effectiveness of our approach using three publicly available datasets: Kvasir-SEG, FLAIR MRI Low-Grade Glioma (LGG), and ISIC 2018 datasets. In our evaluation, we have compared the performance of our loss function against four different loss functions. Furthermore, we have showcased the excellence of our approach by comparing it with various state-of-the-art methods.
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http://dx.doi.org/10.1016/j.compbiomed.2024.108305 | DOI Listing |
Sleep
January 2025
Department of Psychology, Faculty of Science, Memorial University, St. John's, NL, Canada.
Study Objectives: Cancer-related fatigue is one of the most common symptoms in cancer survivors. Cognitive behavioural therapy for insomnia (CBT-I) can improve fatigue, but mechanisms are unclear. This secondary analysis of a randomized controlled trial evaluated whether CBT-I led to a significant improvement in fatigue, accounting for change in comorbid symptoms of insomnia, perceived cognitive impairment (PCI), anxiety, and depression.
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January 2025
Ningxia Medical University, Xing Qing Block, Shengli Street No.1160, Yin Chuan City, 750004, Ningxia Province, People's Republic of China.
Background: Colon adenocarcinoma (COAD) is a leading cause of cancer-related mortality worldwide. Transient receptor potential vanilloid 4 (TRPV4), a calcium-permeable non-selective cation channel, has been implicated in various cancers, including COAD. This study investigates the role of TRPV4 in colon adenocarcinoma and elucidates its potential mechanism via the ferroptosis pathway.
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January 2025
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Background: Chronic constipation, diarrhea, and fecal incontinence (FI) are prevalent with significant impact on quality of life and healthcare utilization. Thyroid dysfunction was recognized as a potential contributor to bowel disturbances in selected populations, but the strength/consistency of this association remain unclear.
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Dig Dis Sci
January 2025
Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Background: Ulcerative colitis patients who undergo ileal pouch-anal anastomosis (IPAA) without mucosectomy may develop inflammation of the rectal cuff (cuffitis). Treatment of cuffitis typically includes mesalamine suppositories or corticosteroids, but refractory cuffitis may necessitate advanced therapies or procedural interventions. This review aims to summarize the existing literature regarding treatments options for cuffitis.
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January 2025
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Introduction: Colorectal cancer (CRC) is the second most common cause of cancer-related deaths globally. The gut microbiota, along with adenomatous polyps (AP), has emerged as a plausible contributor to CRC progression. This study aimed to scrutinize the impact of the FadA antigen derived from Fusobacterium nucleatum on the expression levels of the ANXA2 ceRNA network and assess its relevance to CRC advancement.
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