Background And Objective: Many recent studies in virtual reality (VR) have managed the sense of Presence to assess the suitability of their designs, mainly when focused on learning goals that require high user engagement, such as in serious games for psychomotor training. However, the place and plausibility illusions needed to promote Presence are achieved by combining different VR-based design cues, and their individual contribution to preserving the Presence's engagement/involvement component is still unclear. This article explored the single effect of breaking the sense of Presence per VR factor, i.e., removing VR cues related to Social Presence (human interactions), Self-Presence (embodiment), and Physical Presence (Scenario realism).
Methods: Thirty-three participants were asked to play an immersive VR simulation of an arcade game three times by experiencing a stepped Break of Illusion in one of the VR factors, i.e., while two factors were kept high, the remaining one was reduced to a low and null (hypothetical) level. The game difficulty was fixed after assessing each person's skills.
Results: Results showed that psychophysiology indicators (heart rate and skin conductance) were not affected by the level of illusion, whereas exercise intensity was significantly higher with low body and social presence-based conditions. Moreover, skin conductance was lower in the Social-presence group, which suggests that perspiration is only affected by breaks in realism (scenario and body representations). Based on the obtained evidence, we proposed some guidelines for adapting the design of immersive virtual environments through Breaks in Presence, mainly by changing the realism of the scenario and body representation depending on the skin conductance or the interaction with virtual humans depending on exercise intensity.
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http://dx.doi.org/10.1016/j.cmpb.2024.108124 | DOI Listing |
BMC Cancer
January 2025
Young Academy of Gynecologic Oncology (JAGO), Nord-Ostdeutsche Gesellschaft für Gynäkologische Onkologie (NOGGO), Berlin, Germany.
Background: The integration of immune checkpoint inhibitors (ICIs) into routine gynecologic cancer treatment requires a thorough understanding of how to manage immune-related adverse events (irAEs) to ensure patient safety. However, reports on real-world clinical experience in the management of ICIs in gynecologic oncology are very limited. The aim of this survey was to provide a real-world overview of the experiences and the current state of irAE management of ICIs in Germany, Switzerland, and Austria.
View Article and Find Full Text PDFAesthetic Plast Surg
January 2025
Department of Plastic and Reconstructive Surgery, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Background: Hyaluronidase remains the mainstay treatment for impending filler-induced facial skin necrosis. Complete resolution of impending skin necrosis following hyaluronidase injection is estimated to be around 77.8%.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Textile and Clothing Engineering, Soochow University, 199 Ren-ai Road, Suzhou 215123, China; Jiangsu Engineering Research Center of Textile Dyeing and Printing for Energy Conservation, Discharge Reduction and Cleaner Production (ERC), 215123, China; State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China. Electronic address:
Conductive organohydrogel fibers based on sodium alginate (SA) exhibit remarkable flexibility and electrical conductivity, making them ideal candidates for conformal skin adhesion and real-time monitoring of human activity signals. However, traditional conductive hydrogels often suffer from issues such as uneven distribution of conductive fillers, and achieving the integration of high mechanical strength, stretchability, and transparency using environmentally friendly methods remains a significant challenge. In this study, a novel and sustainable strategy was developed to fabricate dual-network organohydrogel fibers using sodium alginate as the primary material.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
The Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, Guangdong Province 511518, China. Electronic address:
Gelatin/κ-carrageenan (Gel/KC) hydrogel has exhibited a significant potential in tissue engineering, however, there is still a need to further enhance its structural properties. This study developed a Gel/KC dual-network hydrogel with superior mechanical properties and structural stability, which was integrated with 3D printing to evaluate its ability to promote wound healing. The hydrogels with seven different Gel and KC ratios were prepared and characterized using rheological testing, thermal analysis, spectral analysis, micromorphology observation, and X-ray diffraction.
View Article and Find Full Text PDFVaccine
January 2025
Medical Technology Innovation Center, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address:
This study was conducted at 112 government and Juntendo University hospitals in February 2021 for the primary series of SARS-CoV-2 vaccinations. We compared the timing of solicited adverse event (AE) onset and prevalence of unsolicited AEs for Pfizer, Moderna, and AstraZeneca vaccines in a nationwide, large-scale prospective cohort study. The Pfizer and Moderna mRNA vaccines were associated with a higher frequency of fever after the second dose than after the first dose.
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