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Burden of Infections in Early Life and Risk of Infections and Systemic Antibiotics Use in Childhood.
JAMA Netw Open
January 2025
Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Importance: A high infection burden in early childhood is common and a risk factor for later disease development. However, longitudinal birth cohort studies investigating early-life infection burden and later risk of infection and antibiotic episodes are lacking.
Objective: To investigate whether early-life infection burden is associated with a later risk of infection and systemic antibiotic treatment episodes in childhood.
Pediatric Case of Facial Nerve Palsy as a Complication of Acute Otitis Media Caused by Non-typeable Haemophilus Influenza.
Cureus
January 2025
Department of Microbiology, Medical University-Sofia, Sofia, BGR.
Facial paralysis is an infrequent and serious potential complication of acute otitis media (AOM). We describe a pediatric case of rapidly progressive facial paralysis as a secondary complication alongside AOM, caused by the non-typeable (NTHi) strain, which was managed with facial nerve decompression, glucocorticoid medication, and antimicrobial chemotherapy. The reasons why NTHi becomes pathogenic in certain patients are not yet fully understood, and the specific interactions and adaptations that lead to complications must be further investigated, as they result in more complex treatment approaches.
View Article and Find Full Text PDFHealth state utilities associated with invasive pneumococcal disease, pneumonia, and recurrent acute otitis media in young children.
Qual Life Res
January 2025
MRL, Merck & Co., Inc., Rahway, NJ, USA.
Purpose: Cost-utility analyses examining the value of new vaccines for pneumococcal disease will require health state utilities as inputs. Existing utilities for pneumococcal infections in young children are limited. The purpose of this study was to estimate health state utilities associated with pneumococcal infections in young children.
View Article and Find Full Text PDFManagement of intracranial and orbital complications of acute rhinosinusitis and acute otitis media in the post covid-19 era in pediatric patients.
Eur Arch Otorhinolaryngol
December 2024
Division of Neurosurgery, Department of Translational Biomedicine and Neurosciences (DiBraiN), University "Aldo Moro" of Bari, Bari, 70124, Italy.
Purpose: Acute bacterial rhinosinusitis (ABRS) and acute otitis media (AOM) are common diseases in pediatric populations that rarely lead to intracranial infection and/or orbital complications. The incidence of these complications has increased in recent years and the main aim of this study is to analyze the tendency of this increase during the pandemic years, compared with the pre-pandemic era and to propose our management of ABRS and AOM.
Method: Clinical data from children, admitted to our hospital during the period from January 2018 to March 2024 with a diagnosis of complicated ABRS and AOM was collected.
Pediatric Acute Otitis Media Clinical Trials: An Analysis of Diversity.
Otolaryngol Head Neck Surg
December 2024
Department of Otolaryngology-Head and Neck Surgery, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
Objective: This study aims to assess the diversity and equity of pediatric acute otitis media (AOM) trials using ClinicalTrials.gov, focusing on participant demographics and representation to identify gaps in inclusivity and inform strategies for promoting diversity in future pediatric AOM studies.
Study Design: Retrospective analysis.
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