Necrotizing enterocolitis (NEC) is the most often encountered pathology of newborns and always requires an emerging surgery in cases of perforation. An active study of more important diagnostic factors at early stages of a disease is one of the first aims of neonatologists and pediatric surgeons. This study was therefore designed to examine the state of diagnostic problems in patients presenting with Necrotizing enterocolitis, identification of possible ways of the improvement of a patient's diagnosis suffering from Necrotizing enterocolitis and patients with perforated enterocolitis, definition of the possibilities of roentgenologic methods for the determination of a disease stage of Necrotizing enterocolitis. 69 infants aged one day to 1.5 months admitted at surgical department of K.Y. Farajeva Research Institute of Pediatrics between 2016 and 2021 inclusive were treated and evaluated. The capabilities of plain radiography and using radiocontrast methods of study to reveal NEC stages have been evaluated. The use of CSM has advantages: simplicity and accessibility in use, high diagnostic informativeness, identification of objective signs of NEC in 2-3 hours of research, allows assessing the severity of the patient's condition at an early date and timely correct treatment.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Bronchopulmonary dysplasia (BPD) is a chronic lung disease, with its own clinical, radiological and histopathological characteristics, which mainly affects premature newborns, resulting from a combination of factors that include immaturity, inflammation and lung injury, in addition to therapy with mechanical ventilation and exposure to high concentrations of oxygen. However, even with advances in care for critically ill newborns, BPD continues to be a challenge for the care team and family members. This has been identified as one of the most important causes of morbidity and mortality due to prematurity, and can have significant impacts on the quality of life of the affected patients.
View Article and Find Full Text PDFVitamin A enhances PI3K/Akt signaling and mitigates enterocyte apoptosis in a mouse model of necrotizing enterocolitis.
Pediatr Surg Int
January 2025
Department of Neonatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China.
Purpose: This study aims to elucidate the roles of the PI3K-Akt signaling pathway and enterocyte apoptosis in necrotizing enterocolitis (NEC) pathogenesis and investigate the impact of vitamin A intervention on these factors.
Methods: We employed an NEC mouse model and administered vitamin A treatment. Retinol levels in mouse blood were quantified using ELISA.
Bovine Colostrum in Pediatric Nutrition and Health.
Nutrients
December 2024
Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Çanakkale 17000, Türkiye.
Bovine colostrum (BC), the first milk secreted by mammals after birth, is a trending alternative source for supplementing infants and children, offering benefits for gut and immune health. Its rich components, such as proteins, immunoglobulins, lactoferrin, and glycans, are used to fortify diets and support development. Preterm development is crucial, especially in the maturation of essential systems, and from 2010 to 2020, approximately 15% of all premature births occurred at less than 32 weeks of gestation worldwide.
View Article and Find Full Text PDFRole of Human Milk Microbiota in Infant Neurodevelopment: Mechanisms and Clinical Implications.
Children (Basel)
November 2024
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16126 Genoa, Italy.
Background: Human milk (HM) is recognized as an ideal source of nutrition for newborns; as a result, its multiple bioactive molecules can support the growth of healthy newborns and reduce the risk of mortality and diseases such as asthma, respiratory infections, diabetes (type 1 and 2), and gastrointestinal disorders such as ulcerative colitis and Crohn's disease. Furthermore, it can reduce the severity of necrotizing enterocolitis (NEC) in preterm infants. Moreover, human milk oligosaccharides (HMOs) present in breast milk show an immunomodulatory, prebiotic, and neurodevelopmental effect that supports the microbiota-gut-brain axis.
View Article and Find Full Text PDFUsing Vital Signs for the Early Prediction of Necrotizing Enterocolitis in Preterm Neonates with Machine Learning.
Children (Basel)
November 2024
Department of Neonatology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Background/objectives: Necrotizing enterocolitis (NEC), a devastating neonatal gastrointestinal disease mostly seen in preterm infants, lacks accurate prediction despite known risk factors. This hinders the possibility of applying targeted preventive therapies. This study explores the use of vital signs, including cerebral and splanchnic oxygenation, measured with near-infrared spectroscopy in early NEC prediction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!