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| http://dx.doi.org/10.1093/ckj/sfae048 | DOI Listing |
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Severe hypophosphataemia following denosumab administration successfully managed using a calcimimetic agent.
BMJ Case Rep
January 2025
Pediatrics, Shiga University of Medical Science, Otsu, Shiga, Japan.
Denosumab, an anti-RANKL antibody, induces bone metabolism to a low-turnover bone status by arresting osteoclast activity. Frequent adverse events include infusion reactions, fever and hypocalcaemia but not hypophosphataemia. We report a case of severe hypophosphataemia associated with secondary hyperparathyroidism following denosumab administration in a young boy with recurrent osteosarcoma who was successfully treated with evocalcet.
View Article and Find Full Text PDFExploration of factors affecting denosumab-induced hypocalcemia in male patients with osteoporosis using a hospital-based administrative claims database.
Maturitas
December 2024
Division of Drug Informatics, Keio University Faculty of Pharmacy, Graduate School of Pharmaceutical Sciences, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. Electronic address:
Objectives: Factors affecting denosumab-induced hypocalcemia in male patients with osteoporosis remain unclear because of the small patient population. Nevertheless, it is important to explore male-specific risk factors. This study aimed to identify the factors affecting the development of denosumab-induced hypocalcemia in male patients with osteoporosis and compare them with those in female patients with osteoporosis.
View Article and Find Full Text PDFDenosumab-Induced Recurrent Severe Hypocalcaemia in a Patient With Chronic Kidney Disease: A Case Report.
Cureus
November 2024
Diabetes and Endocrinology, Midland Metropolitan University Hospital, Birmingham, GBR.
Denosumab is a human monoclonal immunoglobulin G2 (IgG2) antibody that is used in the management of osteoporosis and various bone-related disorders to help strengthen bones and prevent fractures. Declining renal function and the drug denosumab are both associated with an increased risk of hypocalcaemia. The combination of both factors in a patient, along with the long half-life of the drug, can cause further exacerbation of this risk.
View Article and Find Full Text PDFEffectiveness and safety of denosumab on osteoporosis treatment in kidney transplant recipients.
Kidney Res Clin Pract
November 2024
Division of Nephrology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Republic of Korea.
Background: Denosumab has been reported to improve bone mineral density (BMD), but the clinical impact of denosumab on osteoporosis in kidney transplant recipients (KTRs) remains controversial.
Methods: We analyzed 98 KTRs who used denosumab from 2018 to 2023. We investigated the change in BMD, laboratory findings, complications of denosumab, fracture risk assessment tool (FRAX) score, acute rejection within 1 year, and graft failure.
Influence of loop diuretics on denosumab-induced hypocalcaemia in osteoporosis: a retrospective observational analysis.
J Pharm Health Care Sci
September 2024
Department of Pharmacy, Faculty of Medicine, Mie University Hospital, Mie University, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Article Synopsis
- - The study investigated whether the combination of denosumab (used for osteoporosis) and loop diuretics, which increase calcium excretion in urine, leads to hypocalcaemia (low calcium levels) in patients.
- - An analysis of adverse drug event reports indicated a significant association between loop diuretics and an increased risk of hypocalcaemia in patients taking denosumab, with a reporting odds ratio suggesting a strong correlation.
- - It was found that higher baseline calcium levels and calcium/vitamin D supplementation could lower the risk of hypocalcaemia, while the effect of denosumab on calcium levels was more pronounced when combined with loop diuretics.
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