AI Article Synopsis
- Gender differences can affect the diagnosis, treatment, and long-term outcomes of myasthenia gravis (MG), particularly since women are often diagnosed during childbearing years.
- A literature review highlights that these differences include clinical factors and antibody status, with pregnancy generally being safe for MG patients and good outcomes expected for mothers and infants.
- Close monitoring during pregnancy is crucial to quickly address any potential issues caused by maternal antibodies, emphasizing the need for thorough medical advice and teamwork among healthcare providers for patients planning to have children.
Article Abstract
Background: There is evidence that gender-specific differences can influence the diagnostics, treatment and long-term disease course of myasthenia gravis (MG). In women the diagnosis is often made during childbearing age.
Objective: Gender-specific differences in MG and relevant aspects in routine clinical practice are presented. In addition, current studies on family planning, pregnancy and childbirth in MG are highlighted and treatment recommendations are derived.
Material And Methods: Narrative literature review.
Results: In addition to sociodemographic data, gender-specific differences encompass clinical as well as paraclinical factors, such as disease severity and antibody status. With few exceptions pregnancy is possible with good maternal and neonatal outcome. During pregnancy and peripartum, children of MG patients should be closely monitored for early detection and treatment of potential syndromes caused by diaplacental transfer of maternal antibodies.
Conclusion: Gender-specific factors can influence the course of MG. Adequate medical counselling and multidisciplinary collaboration are essential for MG patients who wish to have children.
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| http://dx.doi.org/10.1007/s00115-024-01640-6 | DOI Listing |
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