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Google Trends Assessment of Keywords Related to Smoking and Smoking Cessation During the COVID-19 Pandemic in 4 European Countries: Retrospective Analysis.
Online J Public Health Inform
December 2024
Medical Clinic III, University of Lübeck, Lübeck, Germany.
Background: Smoking is a modifiable risk factor for SARS-CoV-2 infection. Evidence of smoking behavior during the pandemic is ambiguous. Most investigations report an increase in smoking.
View Article and Find Full Text PDFIntegration of host gene regulation and oral microbiome reveals the influences of smoking during the development of oral squamous cell carcinoma.
Front Oncol
October 2024
Guangxi Clinical Research Center for Craniofacial Deformity, Guangxi Medical University, Nanning, China.
Objective: This study aims to investigate the regulation of host gene transcription and microbial changes during the development of oral squamous cell carcinoma (OSCC) associated with smoking.
Methods: The OSCC mouse model and smoking mouse model were established using 200 μg/mL 4-nitroquinoline-1-oxide (4NQO) in drinking water and exposure to cigarette smoke (four cigarettes per session, once a day, 5 days a week). Tongue tissues were harvested at 4 weeks and 16 weeks.
Differential effects of environmental exposures on clinically relevant endophenotypes between sexes.
Sci Rep
September 2024
Institute for Biomedical Informatics, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Sex and gender differences play a crucial role in health and disease outcomes. This study used data from the National Health and Nutrition Examination Survey to explore how environmental exposures affect health-related traits differently in males and females. We utilized a sex-stratified phenomic environment-wide association study (PheEWAS), which allowed the identification of associations across a wide range of phenotypes and environmental exposures.
View Article and Find Full Text PDFRB1 Mutations Induce Smoking-Related Bladder Cancer by Modulating the Cytochrome P450 Pathway.
Environ Toxicol
December 2024
Department of Environmental Genomics and Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Article Synopsis
- Cigarette smoking directly increases mutation burden in bladder cancer, specifically affecting driver mutations like RB1, which sees a twofold increase in mutation rates among smokers under 65 years.
- The study utilized various genomic databases and experiments to analyze how these mutations influence tumor growth and the immune environment in bladder cancer patients.
- Findings indicate that RB1 mutations hinder the cytochrome P450 pathway and alter immune cell interactions, potentially enhancing cancer development linked to smoking.
Yorkshire Lung Screening Trial (YLST) pathway navigation study: a protocol for a nested randomised controlled trial to evaluate the effect of a pathway navigation intervention on lung cancer screening uptake.
BMJ Open
July 2024
Wolfson Institute of Population Health, Queen Mary University, London, UK.
Introduction: Lung cancer is the most common cause of cancer death globally. In 2022 the UK National Screening Committee recommended the implementation of a national targeted lung cancer screening programme, aiming to improve early diagnosis and survival rates. Research studies and services internationally consistently observe socioeconomic and smoking-related inequalities in screening uptake.
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