AI Article Synopsis
- - The study investigated the use of angiotensin II type 2 and type 4 receptor antihypertensive medications among U.S. adults with hypertension, focusing on racial and ethnic differences in usage patterns.
- - Data was collected from 24,581 individuals diagnosed with hypertension who did not have dementia or Alzheimer's disease, revealing that non-Hispanic Black and Asian American populations were more likely to use stimulatory antihypertensive agents compared to non-Hispanic Whites.
- - Findings indicated that non-Hispanic Black and Asian Americans had significantly higher odds of being prescribed stimulatory agents, whereas Hispanics were less likely to be prescribed inhibitory agents compared to non-Hispanic Whites, suggesting potential disparities in medication prescribing practices
Article Abstract
Objectives: Studies showed angiotensin II type 2 receptor/angiotensin II type 4 receptor (AT2R/AT4R) stimulatory antihypertensive was associated with a lower risk of dementia and cognitive impairment compared to the inhibitory one. This study aimed to identify the racial and ethnic differences in using these agents among the USA adults with hypertension.
Methods: A cross-sectional study was conducted using data from the Medical Expenditure Panel Survey (MEPS, 2016-2019). Individuals with a diagnosis of hypertension or self-reported hypertension and without dementia or Alzheimer's disease diagnosis were included in the analysis. We applied two multivariable logistic regressions to compare racial/ethnic differences in AT2R/AT4R stimulatory antihypertensive use and AT2R/AT4R inhibitory antihypertensive use, adjusting for covariates.
Results: Twenty-four thousand five hundred eighty-one individuals with hypertension and without dementia or Alzheimer's disease were identified. Among non-Hispanic Whites, 72.39% were using AT2R/AT4R inhibitory antihypertensive agents, vs. 66.97% using AT2R/AT4R stimulatory antihypertensive agents. In contrast, both non-Hispanic Black and Asian Americans were using more AT2R/AT4R stimulatory agents than inhibitory ones (16.40% vs. 12.16% and 4.79% vs. 3.43%, respectively). Compared to non-Hispanic White, non-Hispanic Black (OR 1.980, 95% CI 1.839-2.132) and non-Hispanic Asian Americans (OR 1.545, 95% CI 1.356-1.761) were significantly associated with higher odds of prescribing AT2R/AT4R stimulatory agents, while Hispanics (OR 0.744, 95% CI 0.685-0.808) were associated with lower odds of prescribing AT2R/AT4R inhibitory agents compared to non-Hispanic Whites.
Conclusions: The results showed that the high-dementia risk populations like non-Hispanic Black and Asian American races are proportionally prescribed with higher use of low-dementia risk antihypertensive agents, compared to non-Hispanic Whites.
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| http://dx.doi.org/10.1007/s40615-024-01970-w | DOI Listing |
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Racial/Ethnic Disparities in Use of Angiotensin II Receptor Type 2/4 Stimulatory Vs. Inhibitory Antihypertensive Among Hypertensive Adults in the USA.
J Racial Ethn Health Disparities
March 2024
Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Article Synopsis
- - The study investigated the use of angiotensin II type 2 and type 4 receptor antihypertensive medications among U.S. adults with hypertension, focusing on racial and ethnic differences in usage patterns.
- - Data was collected from 24,581 individuals diagnosed with hypertension who did not have dementia or Alzheimer's disease, revealing that non-Hispanic Black and Asian American populations were more likely to use stimulatory antihypertensive agents compared to non-Hispanic Whites.
- - Findings indicated that non-Hispanic Black and Asian Americans had significantly higher odds of being prescribed stimulatory agents, whereas Hispanics were less likely to be prescribed inhibitory agents compared to non-Hispanic Whites, suggesting potential disparities in medication prescribing practices
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