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Infographic: Efficacy and safety of high-dose Intravitreal aflibercept 8 mg in patients with neovascular age-related macular degeneration: week 48 results from the phase 3 PULSAR trial.
Eye (Lond)
January 2025
Bayer Consumer Care AG, Basel, Switzerland.
E2A, VA RNA I, and L4-22k adenoviral helper genes are sufficient for AAV production in HEK293 cells.
Mol Ther Methods Clin Dev
December 2024
Schepens Eye Research Institute, Mass Eye and Ear Infirmary, Boston, MA, USA.
The replication-defective adeno-associated virus (AAV) is extensively utilized as a research tool or vector for gene therapy. The production process of AAV remains intricate, expensive, and mechanistically underexplored. With the aim of enhancing AAV manufacturing efficiencies in mammalian cells, we revisited the questions and optimization surrounding the requirement of the various adenoviral helper genes in enabling AAV production.
View Article and Find Full Text PDFIntraoperative Electrical Stapedius Reflex Testing to Monitor Cochlear Nerve Integrity during Simultaneous Vestibular Schwannoma Resection and Cochlear Implantation.
Otol Neurotol
January 2025
Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN.
Objective: To compare the utility of intraoperative electrically evoked auditory brainstem response (eABR) and electrically evoked stapedial reflex testing (eSRT) for cochlear nerve integrity monitoring during simultaneous translabyrinthine resection of vestibular schwannoma (VS) and cochlear implantation.
Study Design: Historical cohort study.
Setting: Tertiary academic referral center.
Clinical Use of Home OCT Data to Manage Neovascular Age-Related Macular Degeneration.
J Vitreoretin Dis
December 2024
Retina Consultants of Texas, Houston, TX, USA.
To investigate how home optical coherence tomography (OCT) influences the clinical decision-making of retina specialists for the management of neovascular age-related macular degeneration (nAMD). In this retrospective imaging review, 15 retina specialists each evaluated 10 home OCT data segments from 29 eyes being treated for nAMD. Based on OCT data, indications were identified for when eyes should be treated, which antivascular endothelial growth factor should be used, and the specific retinal fluid and time thresholds for notification.
View Article and Find Full Text PDFInner Ear Gene Therapy: An Overview from Bench to Bedside.
Mol Diagn Ther
December 2024
Christian Doppler Laboratory for Inner Ear Research, Department of Otolaryngology, Head and Neck Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
Hearing loss represents a highly prevalent and debilitating sensory disorder affecting roughly one in five people worldwide. In a majority of patients with congenital hearing loss, genetic mutations cause the disease. Up until recently, therapeutic options for individuals with hearing loss were limited to hearing aids and different types of auditory implants.
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