AI Article Synopsis
- Portal vein thrombosis (PVT) is a frequent complication following splenectomy in patients with cirrhosis, but the factors that predict its occurrence are not well understood.
- A study involving 45 patients who underwent splenectomy identified that a portal vein diameter (PVD) of ≥ 14.5 mm and a MELD score greater than 10 are significant predictors of PVT at 1, 3, and 12 months post-surgery.
- The research showed a cumulative incidence of PVT increasing over time, with notable differences based on MELD scores and PVD measurements, suggesting closer monitoring for patients with these risk factors.
Article Abstract
Background: Portal vein thrombosis (PVT) is a commonthsn complication after splenectomy in patients with cirrhosis. However, the predictors of postoperative PVT are not known.
Aim: To investigate the predictors of PVT after splenectomy in patient with cirrhosis.
Methods: A total of 45 patients with cirrhosis who underwent splenectomy were consecutively enrolled from January 2017 to December 2018. The incidence of PVT at 1 months, 3 months, and 12 months after splenectomy in patients with cirrhosis was observed. The hematological indicators, biochemical and coagulation parameters, and imaging features were recorded at baseline and at each observation point. The univariable, multivariable, receiver operating characteristic curve and time-dependent curve analyses were performed.
Results: The cumulative incidence of PVT was 40.0%, 46.6%, and 48.9% at 1 months, 3 months, and 12 months after splenectomy. Multivariable analysis showed that portal vein diameter (PVD) ≥ 14.5 mm and monthsdel end-stage liver disease (MELD) score > 10 were independent predictors of PVT at 1 months, 3 months, and 12 months after splenectomy ( < 0.05). Time-dependent curve showed that the cumulative incidence of PVT was significantly different between patients with MELD score ≤ 10 and > 10 ( < 0.05). In addition, the cumulative incidence of PVT in the PVD ≥ 14.5 mm group was significantly higher than that in the PVD < 14.5 mm group ( < 0.05).
Conclusion: Wider PVD and MELD score > 10 were independent predictors of PVT at 1 months, 3 months, and 12 months after splenectomy in patient with cirrhosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941749 | PMC |
| http://dx.doi.org/10.4254/wjh.v16.i2.241 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!