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The role of zygotic genome activation in genetic-related reproductive medicine: Technological perspective, religious and bioethical concerns, challenges and benefits. | LitMetric

The role of zygotic genome activation in genetic-related reproductive medicine: Technological perspective, religious and bioethical concerns, challenges and benefits.

J Genet Eng Biotechnol

Cihan University Sulaimaniya Research Center (CUSRC), Cihan University - Sulaimaniya, Kurdistan Region 46001, Iraq; College of Health Sciences, Cihan University-Sulaimaniya, Kurdistan Region, Iraq. Electronic address:

Published: March 2024

AI Article Synopsis

  • - Zygotic Genome Activation (ZGA) is a key developmental stage in early embryogenesis where control shifts from maternal to embryonic genes, essential for cell differentiation and development.
  • - Recent advances in genomics have linked ZGA to genetic screening techniques like preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS), which help identify genetic issues before embryo implantation.
  • - Innovations in sequencing technologies allow for better understanding of gene expression changes during ZGA, enhancing the potential to detect and address genetic disorders early in human development, ultimately improving reproductive success.

Article Abstract

Zygotic Genome Activation (ZGA) is a crucial developmental milestone in early embryogenesis, marking the transition from maternal to embryonic control of development. This process, which varies in timing across species, involves the activation of the embryonic genome, paving the way for subsequent cell differentiation and organismal development. Recent advances in genomics and reproductive medicine have highlighted the potential of ZGA in the realm of genetic screening, providing a window into the genetic integrity of the developing embryo at its earliest stages. The intersection of ZGA and genetic screening primarily emerges in the context of preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS). These techniques, often employed during assisted reproductive technologies, aim to detect potential genetic abnormalities or chromosomal imbalances before embryo implantation. Given that ZGA represents the onset of embryonic gene expression, understanding its intricacies can significantly enhance the accuracy and predictive power of these screening processes. With the advent of next-generation sequencing and other high-throughput genomic techniques, detailed mapping of the transcriptomic changes during ZGA has become feasible. Such advancements have deepened our insights into the dynamics of early embryonic development and the onset of genetic disorders. As our knowledge in this realm expands, it promises to revolutionize our capabilities in detecting, understanding, and potentially rectifying genetic anomalies at the earliest stages of human life, thereby optimizing reproductive outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10980863PMC
http://dx.doi.org/10.1016/j.jgeb.2023.100340DOI Listing

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