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http://dx.doi.org/10.1111/cod.14542 | DOI Listing |
Integr Environ Assess Manag
January 2025
Institute of Environmental Toxicology, Western Washington University, Bellingham, Washington, USA.
Traditional ecological and human health risk assessment often relies on deterministic frameworks that preclude the presence of variability or uncertainty among input parameters characterizing exposure, effects, and risk. To promote increased realism and generate more robust risk management decisions, probabilistic risk assessment (PRA) has been introduced as a foundational grouping of techniques that seeks to broadly characterize variability among its components. While multiple methods exist (e.
View Article and Find Full Text PDFmSystems
January 2025
Department of Ecology, Behavior and Evolution, University of California San Diego School of Biological Sciences, La Jolla, California, USA.
Unlabelled: Biological diversity is declining across the tree of life, including among prokaryotes. With the increasing awareness of host-associated microbes as potential regulators of eukaryotic host physiology, behavior, and ecology, it is important to understand the implications of declining diversity within host microbiomes on host fitness, ecology, and ecosystem function. We used phytoplankton and their associated environmental microbiomes as model systems to test the independent and interactive effects of declining microbiome diversity with and without other stressors often caused by human activity-elevated temperature and altered nutrient availability.
View Article and Find Full Text PDFFront Cardiovasc Med
January 2025
Department of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL, United States.
Background: Effective management of dual antiplatelet therapy (DAPT) following drug-eluting stent (DES) implantation is crucial for preventing adverse events. Traditional prognostic tools, such as rule-based methods or Cox regression, despite their widespread use and ease, tend to yield moderate predictive accuracy within predetermined timeframes. This study introduces a new contrastive learning-based approach to enhance prediction efficacy over multiple time intervals.
View Article and Find Full Text PDFImmunotargets Ther
January 2025
Institute of Integration of Traditional Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, People's Republic of China.
Introduction: Cancer is a widespread epidemic that affects millions of individuals across the world. Identifying novel cancer targets is crucial to developing more effective cancer treatments. Platelet-derived growth factor-B (PDGFB) plays a critical role in various tumor processes, including angiogenesis and lymphatic metastasis.
View Article and Find Full Text PDFSci Rep
January 2025
Acoustics Research Centre, University of Salford, The Crescent, Manchester, M5 4WT, UK.
It is well understood that a significant shift away from fossil fuel based transportation is necessary to limit the impacts of the climate crisis. Electric micromobility modes, such as electric scooters and electric bikes, have the potential to offer a lower-emission alternative to journeys made with internal combustion engine vehicles, and such modes of transport are becoming increasingly commonplace on our streets. Although offering advantages such as reduced air pollution and greater personal mobility, the widespread approval and uptake of electric micromobility is not without its challenges.
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