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Ambulatory Routine Care in Oncology in Germany: Real-World Survival Data. | LitMetric

Ambulatory Routine Care in Oncology in Germany: Real-World Survival Data.

Oncol Res Treat

Berufsverband der Niedergelassenen Ärztinnen und Ärzte für Hämatologie und Medizinische Onkologie in Deutschland e.V. (BNHO e.V.), Cologne, Germany.

Published: August 2024

AI Article Synopsis

  • Survival data from randomized controlled trials may not directly apply to real-world patients due to differences in patient populations, leading to an efficacy-effectiveness gap.
  • A study analyzed survival outcomes of 11,679 patients with various advanced cancers receiving treatment in Germany's routine care from 2006 to 2020, comparing their outcomes with those reported in clinical trials.
  • The findings indicated that overall survival for many cancer types in routine care was comparable to clinical trial results, although a few cancers had slightly lower survival rates in everyday practice.

Article Abstract

Introduction: Survival data reported by randomised controlled trials are collected in a highly selected patient population and can thus only be transferred to a limited extent to real-world patients: the patients in routine care are mostly older, present with more comorbidities and a worse general state of health. This so-called efficacy-effectiveness gap typically results in inferior survival data in routine healthcare.

Methods: Six prospective clinical tumour registries recruited a total of 11,679 patients receiving systemic therapy in haemato-oncological practices in Germany between 2006 and 2020. For these patients with advanced colorectal cancer, breast cancer, lung cancer, pancreatic cancer, renal cell cancer, and lymphatic neoplasms, overall survival was analysed. A comprehensive literature search was performed to identify suitable pivotal randomised controlled trials.

Results: Median overall survival of patients treated in German routine care, with advanced colorectal, breast, lung, and pancreatic cancer, as well as with diffuse large B-cell lymphoma and multiple myeloma, is not shorter than the respective survival data reported in trials. Patients with advanced renal cell carcinoma, chronic lymphocytic leukaemia, or indolent non-Hodgkin lymphoma showed slightly lower survival rates compared to clinical trials.

Conclusions: Despite less favourable patient characteristics, survival data from patients with cancer treated in ambulatory routine care in Germany are in range with results from randomised controlled studies.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251673PMC
http://dx.doi.org/10.1159/000536652DOI Listing

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