AI Article Synopsis
- * Traditional animal models have limitations in predicting human outcomes due to differences in skin structure and immune responses, which SoC technologies aim to address.
- * The review covers various applications of SoC in studying skin-related issues like infectious diseases, autoimmune conditions, wound healing, drug reactions, and aging, positioning SoC as a valuable alternative for research.
Article Abstract
Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including infectious diseases, autoimmune skin conditions, wound healing, drug toxicity, aging, and antiaging, SoC aims to circumvent the inherent disparities created by traditional models. In this paper, we review current SoC technologies, highlighting their potential as an alternative to animal models for a deeper understanding of complex skin conditions.
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| http://dx.doi.org/10.1016/j.jid.2024.01.031 | DOI Listing |
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