AI Article Synopsis

  • * An observational study of 15,792 individuals found that low serum potassium and magnesium levels were associated with a higher risk of AF, while increased phosphate levels were also linked to greater incidence, but calcium levels showed no correlation.
  • * Despite these associations, the study concluded that serum electrolytes are not causal factors for AF development, suggesting they could be used as prognostic indicators rather than direct causes.

Article Abstract

Background: Atrial fibrillation (AF) is a prevalent arrhythmic condition resulting in increased stroke risk and is associated with high mortality. Electrolyte imbalance can increase the risk of AF, where the relationship between AF and serum electrolytes remains unclear.

Methods: A total of 15,792 individuals were included in the observational study, with incident AF ascertainment in the Atherosclerosis Risk in Communities (ARIC) study. The Cox regression models were applied to calculate the hazard ratio (HR) and 95% confidence interval (CI) for AF based on different serum electrolyte levels. Mendelian randomization (MR) analyses were performed to examine the causal association.

Results: In observational study, after a median 19.7 years of follow-up, a total of 2551 developed AF. After full adjustment, participants with serum potassium below the 5th percentile had a higher risk of AF relative to participants in the middle quintile. Serum magnesium was also inversely associated with the risk of AF. An increased incidence of AF was identified in individuals with higher serum phosphate percentiles. Serum calcium levels were not related to AF risk. Moreover, MR analysis indicated that genetically predicted serum electrolyte levels were not causally associated with AF risk. The odds ratio for AF were 0.999 for potassium, 1.044 for magnesium, 0.728 for phosphate, and 0.979 for calcium, respectively.

Conclusions: Serum electrolyte disorders such as hypokalemia, hypomagnesemia and hyperphosphatemia were associated with an increased risk of AF and may also serve to be prognostic factors. However, the present study did not support serum electrolytes as causal mediators for AF development.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10944597PMC
http://dx.doi.org/10.1186/s12864-024-10197-2DOI Listing

Publication Analysis

Top Keywords

serum electrolyte
16
serum
10
risk
9
atrial fibrillation
8
mendelian randomization
8
serum electrolytes
8
observational study
8
electrolyte levels
8
associated risk
8
study
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!