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Effect of dexpanthenol on cyclophosphamide-induced ovarian toxicity: a histological and molecular study in rats. | LitMetric

Effect of dexpanthenol on cyclophosphamide-induced ovarian toxicity: a histological and molecular study in rats.

Reprod Biomed Online

Tokat Gaziosmanpasa University, Artova Vocational School, Department of Veterinary, Medicine, Laboratory and Veterinary Health Program, 60670, Tokat, Turkey.

Published: May 2024

AI Article Synopsis

  • The study investigates whether dexpanthenol can counteract premature ovarian failure (POF) caused by cyclophosphamide (CYC) in female rats.
  • 28 rats were divided into four groups, with two groups receiving CYC and two also receiving dexpanthenol, to assess its therapeutic effects over a specific treatment period.
  • Results indicated that dexpanthenol effectively reversed CYC-induced ovarian damage and influenced key proteins associated with apoptosis and oxidative stress, suggesting it may be a potent treatment for POF, but further research is needed before clinical application.

Article Abstract

Research Question: Does dexpanthenol work as an effective therapeutic agent against cyclophosphamide (CYC)-induced premature ovarian failure (POF) in rats?

Design: A total of 28 female Wistar Albino rats were randomly divided into four groups (n = 7 per group). The POF and POF plus dexpanthenol groups were intraperitoneally administered CYC at an initial dose of 50 mg/kg, followed by 8 mg/kg for 14 days. The dexpanthenol and POF plus dexpanthenol groups were both intraperitoneally administered dexpanthenol at a dose of 500 mg/kg/day for 15 days.

Results: In the group administered CYC, the following was observed: a decrease in the ovarian index; a decrease in the numbers of primordial, primary, secondary and antral follicles; an increase in the number of corpus luteum and atretic follicles; a decrease in proliferation cell nuclear antigen immunoreactivity; a significant reduction in anti-Müllerian hormone and oestradiol levels; and an increase in serum FSH levels compared with controls. Dexpanthenol, on the other hand, reversed these effects. Quantitative reverse transcription polymerase chain reaction analyses showed that dexpanthenol increased Bcl-2, Akt1, mTOR, Nrf2 and HO-1 in CYC-induced ovarian tissues, but decreased Bax, Cas3, Hsp27, Hsp70, and Hsp90. Dexpanthenol treatment has a potential for inhibiting the intrinsic apoptotic pathway and oxidative stress levels in ovarian tissues via the downregulation of the mRNA expression of heat shock proteins and the activation of Nrf2/HO-1 pathways.

Conclusions: Our findings demonstrated that dexpanthenol is an effective agent against POF caused by CYC; however, further experimental and clinical data are needed to use it effectively.

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Source
http://dx.doi.org/10.1016/j.rbmo.2023.103778DOI Listing

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