AI Article Synopsis
- The study analyzed the distribution of mitochondrial markers (Drp-1, Mfn-2, PGC-1α) in pyramidal neurons of the hippocampus in mice, focusing on the effects of β-amyloid peptide 25-35.
- Significant changes were noted in the CA3 area on day 38, where levels of the fission marker decreased and fusion marker increased.
- In the CA1 area, a notable reduction in PGC-1α suggests a drop in mitochondrial biogenesis, hinting at potential early changes linked to memory issues in Alzheimer's disease.
Article Abstract
We performed a comparative assessment of the immunohistochemical distribution of markers of mitochondrial fission (Drp-1), mitochondrial fusion (Mfn-2), and mitochondrial biogenesis (PGC-1α) in pyramidal neurons of different zones of the hippocampus in mice with intrahippocampal administration of β-amyloid peptide 25-35. The most pronounced changes in the dynamics associated with a decrease in the amount of the fission marker and an increase in the amount of the fusion marker were observed in the CA3 field on day 38 after peptide administration. In the CA1 field, a significant decrease in the marker of mitochondrial biogenesis PGC-1α was found on day 38, which can indicate a decrease in the intensity of mitochondrial biogenesis. Early mitochondrial changes can play an important role in the pathogenesis of all types of memory impairment in Alzheimer's disease.
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| http://dx.doi.org/10.1007/s10517-024-06060-9 | DOI Listing |
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