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[Heart failure: innovative understanding from traditional Chinese medicine (TCM) and treatment with classic TCM formulas].
Zhongguo Zhong Yao Za Zhi
December 2024
Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.
The prevalence of cardiovascular diseases in China has shown a rising trend. With the patient number of about 8.9 million, heart failure has brought a heavy burden to public health and wellness.
View Article and Find Full Text PDFNext-generation pharmaceuticals: the rise of sildenafil citrate ODF for the treatment of men with erectile dysfunction.
Ther Deliv
January 2025
Global Specialty Excellence, Viatris Inc, New York, USA.
Orodispersible film (ODF) is one of the novel formulations that disintegrate rapidly in the mouth without the requisite for water compared to other conventional oral solid dosage formulations. This delivery system serves as a convenient mode of administration, especially in patients who have dysphagia and fluid restriction, being beneficial to pediatric, geriatric, and bedridden patients. A novel sildenafil ODF containing sildenafil citrate is formulated to be used in patients with erectile dysfunction (ED).
View Article and Find Full Text PDFPostoperative Opioid Consumption After Discharge: An Update From the Michigan Surgical Quality Collaborative Registry.
Ann Surg Open
December 2024
Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
Objective: To evaluate opioid consumption for 21 procedures over 4 years from the Michigan Surgical Quality Collaborative (MSQC) registry and update post-discharge prescribing guidelines.
Background: Opioids remain a common treatment for postoperative pain of moderate-to-severe intensity not adequately addressed by nonopioid analgesics, but excessive prescribing correlates with increased usage. This analysis provides updates and compares patient-reported consumption in response to new guidelines.
Opioid consumption in the first 30 days after surgery was independently associated with new persistent opioid use.
Reg Anesth Pain Med
December 2024
Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan, USA
Article Synopsis
- Previous studies indicate a link between larger opioid prescriptions after surgery and the risk of new persistent opioid use (NPOU), but the connection between NPOU and actual postoperative opioid usage was unclear.
- This study analyzed data from over 36,000 patients who underwent surgery and were opioid naïve prior to their procedures, discovering that 1.3% developed NPOU, with higher opioid consumption in the first 30 days after discharge correlating to an increased risk of NPOU.
- Results suggest that each additional opioid pill taken in the post-surgery period raises the likelihood of developing NPOU, highlighting the critical role of careful opioid prescribing in preventing long-term opioid dependence.
Recovery Residences Are an Innovative Site for HIV Prevention Interventions Targeting People Who Inject Drugs: Preliminary Data From Project HOMES.
AIDS Educ Prev
December 2024
Department of Health Promotion & Behavioral Sciences, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, Houston, Texas.
Of 1.2 million Americans who would benefit from pre-exposure prophylaxis (PrEP), only 36% were prescribed PrEP in 2023. Project HOMES is an ongoing study that evaluates recovery residences for individuals in medication-assisted recovery from opioid use disorder across five Texas cities.
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