AI Article Synopsis
- Adverse drug reactions (ADRs) are a major public health issue, contributing to hospitalizations and being a leading cause of death, which also adds to healthcare costs globally.
- Genetic variations can affect how well certain drugs work and increase the likelihood of ADRs in patients taking commonly prescribed medications.
- Preemptive pharmacogenetic testing can enhance drug safety and efficacy by helping healthcare providers choose the right medications and dosages, ultimately reducing ADRs and improving patient care.
Article Abstract
Adverse drug reactions (ADRs) are a significant public health concern and a leading cause of hospitalization; they are estimated to be the fourth leading cause of death and increasing healthcare costs worldwide. Carrying a genetic variant could alter the efficacy and increase the risk of ADRs associated with a drug in a target population for commonly prescribed drugs. The use of pre-emptive pharmacogenetic/omic (PGx) testing can improve drug therapeutic efficacy, safety, and compliance by guiding the selection of drugs and/or dosages. In the present narrative review, we examined the current evidence of pre-emptive PGx testing-based treatment for the prevention of ADRs incidence and hospitalization or emergency department visits due to serious ADRs, thus improving patient safety. We then shared our perspective on the importance of preemptive PGx testing in clinical practice for the safe use of medicines and decreasing healthcare costs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10942860 | PMC |
| http://dx.doi.org/10.1038/s41397-024-00326-1 | DOI Listing |
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