Background: There are several imaging-based measurements for patellofemoral height, which are obtained from sagittal images. However, these methods can be misleading with sagittal oblique slices and when the patella is tilted and/or chronically subluxated. This study aimed to describe a simple method of measuring patellar height using axial patellotrochlear overlap (APTO) on MRI.
Methods: A retrospective observational study of 97 knees from 251 patients, excluding those with fractures, massive effusion, or patellofemoral conditions. APTO was measured as follows: (1) patellar length (P) - expressed as the number of axial images showing patellar articular cartilage; (2) trochlear overlap (T) - the number of axial images showing the overlap between patellar articular cartilage and articular cartilage of the lateral trochlea. APTO is the ratio T/P. All measurements were performed independently by six raters on two separate occasions. The raters were two orthopaedic consultants, one knee surgery fellow, two consultant musculoskeletal radiologists, and one radiology fellow. The conventional patellotrochlear index (PTI) was measured as a control for all patients by a senior musculoskeletal radiologist.
Results: The mean APTO value was 36.7% (range 14.2-66.6; standard deviation 11.4). There was a positive correlation with the PTI, Pearson correlation coefficient: 0.76, P < 0.001. Intra-observer reliability was good (intraclass correlation coefficient(ICC): 0.66, 95% confidence interval (CI) 0.54, 0.76, P < 0.001). Inter-observer reliability was fair (ICC: 0.51, 95% CI 0.41, 0.6, P < 0.001).
Conclusions: APTO was shown to be a reliable measurement of patellar height and correlated with existing PTI for patellar height. Measurement of APTO on MRI could be a reliable alternative for the evaluation of patellar height. However, further studies are required to assess its validity in patients with patellofemoral pathology.
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http://dx.doi.org/10.1016/j.knee.2024.02.011 | DOI Listing |
Ann Biomed Eng
January 2025
School of Mechanical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Purpose: To evaluate the mechanical wear of cartilage with different types of degradation.
Methods: Bovine osteochondral explants were treated with interleukin-1β (IL-1β) to mimic inflammatory conditions, with chondroitinase ABC (ChABC) to specifically remove glycosaminoglycans (GAGs), or with collagenase to degrade the collagen network during 5 days of culture. Viscoelastic properties of cartilage were characterized via indentation.
Histochem Cell Biol
January 2025
Department of Forensic Medicine and Forensic Toxicology, Medical University of Silesia, 18 Medyków Street, 40-752, Katowice, Poland.
Cartilage diseases and injuries are considered difficult to treat owing to the low regenerative capacity of this tissue. Using stem cells (SCs) is one of the potential methods of treating cartilage defects and creating functional cartilage models for transplants. Their ability to proliferate and to generate functional chondrocytes, a natural tissue environment, and extracellular cartilage matrix, makes SCs a new opportunity for patients with articular injuries or incurable diseases, such as osteoarthritis (OA).
View Article and Find Full Text PDFSci Rep
January 2025
La Trobe Sport & Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia.
Few studies have explored hip morphology and cartilage composition in female athletes or the impact of asymmetric repetitive loading, such as occurs during softball pitching. The current cross-sectional study assessed bilateral bony hip morphology on computed tomography imaging in collegiate-level softball pitchers ('Pitch1', n = 25) and cross-country runners ('Run', n = 13). Magnetic resonance imaging was used to assess cartilage relaxation times in a second cohort of pitchers ('Pitch2', n = 10) and non-athletic controls ('Con', n = 4).
View Article and Find Full Text PDFJ Shoulder Elbow Surg
January 2025
Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing 100044, China; Key Laboratory of Trauma and Neural Regeneration (Peking University), Ministry of Education, Beijing 100044, China; National Center for Trauma Medicine, Peking University People's Hospital, Beijing 100044, China. Electronic address:
Objective: The bare area is defined as a transverse region within the trochlear notch, serving as an optimal entry point for olecranon osteotomy due to the absence of articular cartilage coverage. However, there is limited research on the morphology and location of the bare area, and there is a lack of intuitive visual description. Thus, the purpose of this study is to delineate anatomical features of the bare area and visualize its morphology and refine the olecranon osteotomy approach.
View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur, GA 30033, USA; Department of Orthopaedics, Emory Musculoskeletal Institute, Emory University, Atlanta, GA 30329, USA. Electronic address:
There is currently no cure or disease-modifying treatment for post-traumatic osteoarthritis (PTOA). This study aims to assess the efficacy of dimethyl fumarate (DMF), a US-FDA approved drug for multiple sclerosis, as a treatment for PTOA. PTOA was induced in male Lewis rats by medial meniscal transection (MMT) surgery, and DMF was intra-articularly administered once, one week following surgery.
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