Upon lymphocyte stimulation, accumulation of intracellular NAD(H) reflects the strength of antigen receptor signals and controls the rate of cell cycle entry and proliferation (see related Research Article by Turner .).
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Low Birth Weight and Related Metabolic Risk Factors, Cardio-Respiratory Fitness and Physical Activity in Adolescents.
Children (Basel)
December 2024
Department of Pediatrics, Federal University of Paraná, Curitiba 80060-000, PR, Brazil.
Background/objectives: The associations between low birth weight (LBW) and the aggregation of metabolic risk factors (MRF) in youth remain ambiguous. Thus, this study analysed the interrelationship among MRF, LBW, and behavioural factors in adolescents.
Methods: The sample of the present cross-sectional study comprised 491 youth (229 males, 262 females) aged 14-17 years.
Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1 ALS mouse model.
Biol Res
November 2024
Center for Integrative Biology, Faculty of Science, Universidad Mayor, Camino la Piramide 5750, P.O.BOX 70086, Huechuraba, Santiago, Chile.
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal paralytic disorder associated with motor neuron death. Mutant superoxide dismutase 1 (SOD1) misfolding and aggregation have been linked to familial ALS, with the accumulation of abnormal wild-type SOD1 species being also observed in postmortem tissue of sporadic ALS cases. Both wild-type and mutated SOD1 are reported to contribute to motoneuron cell death.
View Article and Find Full Text PDFLarge-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.
Wellcome Open Res
October 2023
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Article Synopsis
- Genome-wide association studies have found numerous genetic loci linked to glycemic traits, but connecting these loci to specific genes and biological pathways remains a challenge.
- Researchers conducted meta-analyses of exome-array studies across four glycemic traits, analyzing data from over 144,000 participants, which led to the identification of coding variant associations in more than 60 genes.
- The study revealed significant pathways related to insulin secretion, zinc transport, and fatty acid metabolism, enhancing understanding of glycemic regulation and making data available for further research.
Male Holstein calves fed a milk replacer and pelleted calf starter containing a botanical extract or a direct-fed microbial alone or in combination.
J Dairy Sci
December 2024
Department of Animal Science, North Carolina Agricultural and Technical State University, Greensboro, NC 27411.
Botanical extracts (BE; Apex, Adisseo North America, Atlanta, GA) are known to enhance DMI and gut health, whereas direct-fed microbials (DFM), such as a Lactobacillus acidophilus fermentation product (EX: Excel; Pacer Technology Inc., Murtaugh, ID), have demonstrated improved gut health and growth performance when fed to growing neonatal Holstein calves. The hypothesis was this combination may be synergistic to neonatal calf growth performance and intestinal health.
View Article and Find Full Text PDFA mobile app-based intervention improves anthropometry, body composition and fitness, regardless of previous active-inactive status: a randomized controlled trial.
Front Public Health
August 2024
Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport, Faculty of Sport Sciences, University of Murcia, Murcia, Spain.
Introduction: The use of mobile apps to promote physical activity in adolescents can improve health-related parameters. However, previous studies have not evaluated whether the benefits depend on the users' prior active or inactive status. Therefore, the main objective was to analyze differences in physical activity levels, adherence to the Mediterranean diet (AMD), anthropometry, body composition, and physical fitness between active and inactive adolescents.
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