AI Article Synopsis
- * These oligo-proline mimetics exhibit a right-handed helical conformation influenced by the configuration of the neighboring cyclopentane carboxylic acid unit.
- * Unlike traditional polyproline, these synthetic Pro-Cyp oligomers gain stability from their backbone structure rather than from -π* interactions.
Article Abstract
The synthesis and conformational properties of oligo-proline mimetics composed of dimeric and tetrameric Pro-Cyp constructs linked by a hydroxymethylene unit are reported. Oligomers were studied both in the solid state and in solution, unveiling right-handed helical conformation depending on the configuration of the vicinally substituted -cyclopentane carboxylic acid unit (Cyp). Unlike polyproline oligomers, the alternating synthetic Pro-Cyp counterparts are not stabilized by -π* interactions but rely instead on the steric demands of the extended backbone conformation within the hydroxymethylene-linked Pro-Cyp repeating units.
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| http://dx.doi.org/10.1021/acs.joc.3c02840 | DOI Listing |
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Article Synopsis
- * These oligo-proline mimetics exhibit a right-handed helical conformation influenced by the configuration of the neighboring cyclopentane carboxylic acid unit.
- * Unlike traditional polyproline, these synthetic Pro-Cyp oligomers gain stability from their backbone structure rather than from -π* interactions.
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