Nanozymes are a class of nanomaterials with biocatalytic function and enzyme-like activity, whose advantages include high stability, low cost, and mass production. They can catalyze the substrates of natural enzymes based on specific nanostructures and serve as substitutes for natural enzymes. Their applied research involves a wide range of fields such as biomedicine, environmental governance, agriculture, and food. Molecular logic gates are a new cross-disciplinary discipline, which can simulate the function of silicon circuits on a molecular scale, perform single or multiple input logic operations, and generate logic outputs. A molecular logic gate is a binary operation that converts an input signal into an output signal according to the rules of Boolean logic, generating two signals, a high level, and a low level. The high and low levels represent the "true" and "false" values of the logic gates, and their outputs correspond to "l" and "0" of the molecular logic gates, respectively. The combination of nanozymes and logic gates is a novel and attractive research direction, and the cross-application of the two brings new opportunities and ideas for various fields, such as the construction of efficient biocomputers, intelligent drug delivery systems, and the precise diagnosis of diseases. This review describes the application of logic gates based on nanozymes, which is expected to provide a certain theoretical foundation for researchers' subsequent studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00216-024-05240-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rational Design of Dual-Targeted Nanomedicines for Enhanced Vascular Permeability in Low-Permeability Tumors.
ACS Nano
January 2025
School of Medicine, Nankai University, Tianjin 300071, China.
Designing dual-targeted nanomedicines to enhance tumor delivery efficacy is a complex challenge, largely due to the barrier posed by blood vessels during systemic delivery. Effective transport across endothelial cells is, therefore, a critical topic of study. Herein, we present a synthetic biology-based approach to engineer dual-targeted ferritin nanocages (Dt-FTn) for understanding receptor-mediated transport across tumor endothelial cells.
View Article and Find Full Text PDFHigh-performance ternary logic circuits and neural networks based on carbon nanotube source-gating transistors.
Sci Adv
January 2025
Key Laboratory for the Physics and Chemistry of Nanodevices and Center for Carbon-Based Electronics, School of Electronics, Peking University, Beijing 100871, China.
Multi-valued logics (MVLs) offer higher information density, reduced circuit and interconnect complexity, lower power dissipation, and faster speed over conventional binary logic system. Recent advancement in MVL research, particularly with emerging low-dimensional materials, suggests that breakthroughs may be imminent if multistates transistors can be fabricated controllably for large-scale integration. Here, a concept of source-gating transistors (SGTs) is developed and realized using carbon nanotubes (CNTs).
View Article and Find Full Text PDFLighting Up Dual-Aptamer-Based DNA Logic-Gated Series Lamp Probes with Specific Membrane Proteins for Sensitive and Accurate Cancer Cell Identification.
Anal Chem
January 2025
Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Cixi Biomedical Research Institute, School of Laboratory Medicine and Life sciences, Wenzhou Medical University, Wenzhou 325035, China.
Accurate identification of cancer cells under complex physiological environments holds great promise for noninvasive diagnosis and personalized medicine. Herein, we developed dual-aptamer-based DNA logic-gated series lamp probes (Apt-SLP) by coupling a DNA cell-classifier (DCC) with a self-powered signal-amplifier (SSA), enabling rapid and sensitive identification of cancer cells in a blood sample. DCC is endowed with two extended-aptamer based modules for recognizing the two cascade cell membrane receptors and serves as a DNA logic gate to pinpoint a particular and narrow subpopulation of cells from a larger population of similar cells.
View Article and Find Full Text PDFHigh-Rate Lithium-Ion Capacitor Diode towards Multifrequency Ion/Electron-Coupling Logic Operations.
Angew Chem Int Ed Engl
January 2025
Lanzhou University, No. 222 Tianshui South Road, 730000, Lanzhou, CHINA.
Ion/electron-coupling logic operation is recognized as the most promising approach to achieving in-depth brain-inspired computing, but the lack of high-performance ion/electron-coupling devices with high operating frequencies much restricts the fast development of this field. Accordingly, we herein report an orthorhombic niobium pentoxide (T-Nb2O5) based lithium-ion capacitor diode (CAPode) that possesses thoroughly improved performances to achieve multifrequency ion/electron-coupling logic operations. Specifically, benefiting from the unique crystal structure and fast ion-transport topology of T-Nb2O5, the constructed CAPode exhibits a high response frequency of up to 122 Hz, over three orders of magnitude higher than those of the state-of-the-art CAPodes.
View Article and Find Full Text PDFIRF1 cooperates with ISGF3 or GAF to form innate immune de novo enhancers in macrophages.
Sci Signal
January 2025
Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, USA.
Macrophages exposed to immune stimuli reprogram their epigenomes to alter their subsequent functions. Exposure to bacterial lipopolysaccharide (LPS) causes widespread nucleosome remodeling and the formation of thousands of de novo enhancers. We dissected the regulatory logic by which the network of interferon regulatory factors (IRFs) induces the opening of chromatin and the formation of de novo enhancers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!