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Introduction: Lichen planus pigmentosus (LPP) is an uncommon variant of lichen planus, characterized by the insidious onset of dark brown to gray pigmented macules, mainly in sun-exposed areas and flexural folds. It is mainly reported in Indian, Latino, American, and Middle Eastern patients. This paper aims to document the clinicopathological characteristics of LPP.
View Article and Find Full Text PDFSecondary Syphilis in the Spotlight: Atypical Cutaneous Manifestation Overshadowing Kaposi Sarcoma in a Newly Diagnosed HIV Patient.
Cureus
October 2024
Pathology, Hospital Universitario "Dr. José Eleuterio González", Monterrey, MEX.
Syphilis, caused by the spirochete , is a sexually transmitted infection (STI) that has seen a resurgence worldwide, particularly among populations at a higher risk of co-infection with human immunodeficiency virus (HIV). The disease typically progresses through distinct stages: primary, secondary, latent, and tertiary, each with specific clinical manifestations. Secondary syphilis is characterized by systemic involvement and various mucocutaneous symptoms, including a maculopapular rash that frequently involves the palms and soles along with fever, lymphadenopathy, and mucous membrane lesions.
View Article and Find Full Text PDFCase report: Abrocitinib: a potential therapeutic option for lichen amyloidosis associated with atopic dermatitis.
Front Immunol
November 2024
School of Medicine, Tongji University, Shanghai, China.
Lichen amyloidosis (LA) is a predominant type of primary cutaneous amyloidosis that is characterized by persistent and intense skin itching. Although multiple therapeutics strategies are available for its treatment, there is no standard treatment so far. Abrocitinib, an oral small-molecule Janus kinase 1 inhibitor, has been authorized for the treatment of severe atopic dermatitis (AD) and can also provide rapid relief from pruritus.
View Article and Find Full Text PDFA Challenging Case of Idiopathic Hypereosinophilic Syndrome: An Itching in the Brain.
Cureus
August 2024
Department of Cardiology, All India Institute of Medical Sciences, Nagpur, Nagpur, IND.
Article Synopsis
- Hypereosinophilia (HE) can be challenging to treat, especially when symptoms persist despite low eosinophil counts, necessitating thorough lab testing to uncover potential causes.
- A case study details a 58-year-old woman with diabetes and hypothyroidism who experienced severe itching and skin lesions, initially linked to pyelonephritis, and presented with elevated eosinophil levels resistant to conventional treatments.
- Following extensive mutation studies and a high bone marrow eosinophil count, the patient was successfully treated with imatinib, leading to normalization of eosinophil levels and symptom resolution over the next 1 to 1.5 years.
An Effective Siddha Management for Dermatosis Papulosa Nigra: A Case Report.
Cureus
June 2024
Pathology (Noi Naadal), National Institute of Siddha, Chennai, IND.
Article Synopsis
- * A 70-year-old woman with hyperpigmented papules on her face underwent a Siddha external medicine treatment over five days, experiencing mild discomfort but significant improvement in her lesions after treatment.
- * The study suggests that the Siddha approach may be an effective management option for DPN, with positive treatment responses observed and no adverse effects reported during follow-up.
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