AI Article Synopsis
- This systematic review and meta-analysis focuses on the under-researched area of biological therapy for primary sclerosing cholangitis-inflammatory bowel disease (PSC-IBD) and its historical lack of effective treatment options.
- The review analyzed studies from various sources published up until September 2023, evaluating the roles of biologics and antibiotics, and 9 studies were included with 4 qualifying for deeper analysis.
- The findings indicated that common treatments like infliximab, adalimumab, vedolizumab, and tofacitinib were not effective in improving disease markers, highlighting the need for more research and better treatment strategies in PSC-IBD.
Article Abstract
This is the first systematic review and meta-analysis that aims to address the scarcity of research on the use of biological therapy in primary sclerosing cholangitis-inflammatory bowel disease (PSC-IBD) and the historical inadequacy of therapeutic options. Its purpose is to investigate this matter comprehensively and furnish guidance for clinical practice. Utilizing Embase, PubMed, Medline, and clinicaltrials.gov studies investigating the roles of biologics and antibiotics in PSC-IBD were identified. The systematic literature review encompassed articles published from inception through September 2023. Two independent reviewers assessed the articles, and methodological quality was gauged using Review Manager 5.4.2. Nine studies were included in the systematic review and meta-analysis. However, only four met the criteria for inclusion in the meta-analysis due to variability and availability of data; the remaining studies underwent descriptive analysis. Notably, infliximab, adalimumab, vedolizumab, and tofacitinib showed ineffectiveness in reducing cholestatic markers. This review underscores the limited impact of biological and small-molecule therapies on disease progression in PSC-IBD patients, signifying the need for further exploration and development of treatment modalities in this domain.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10939508 | PMC |
| http://dx.doi.org/10.7759/cureus.56182 | DOI Listing |
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