Intensity and drivers of subtypes interference between seasonal influenza viruses in mainland China: A modeling study.

iScience

Department of Emergency Medicine, Second Affiliated Hospital, Department of Epidemiology and Biostatistics, School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China.

Published: March 2024

AI Article Synopsis

  • * The analysis reveals that interference is more intense in southern China compared to northern China, with significant differences in interference percentages between the two regions.
  • * High relative humidity plays a key role in increasing subtype interference, with southern China experiencing the greatest impact, suggesting that environmental factors can influence virus dynamics.

Article Abstract

Subtype interference has a significant impact on the epidemiological patterns of seasonal influenza viruses (SIVs). We used attributable risk percent [the absolute value of the ratio of the effective reproduction number (Rₑ) of different subtypes minus one] to quantify interference intensity between A/H1N1 and A/H3N2, as well as B/Victoria and B/Yamagata. The interference intensity between A/H1N1 and A/H3N2 was higher in southern China 0.26 (IQR: 0.11-0.46) than in northern China 0.17 (IQR: 0.07-0.24). Similarly, interference intensity between B/Victoria and B/Yamagata was also higher in southern China 0.14 (IQR: 0.07-0.24) than in norther China 0.10 (IQR: 0.04-0.18). High relative humidity significantly increased subtype interference, with the highest relative risk reaching 20.59 (95% CI: 6.12-69.33) in southern China. Southern China exhibited higher levels of subtype interference, particularly between A/H1N1 and A/H3N2. Higher relative humidity has a more pronounced promoting effect on subtype interference.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10937832PMC
http://dx.doi.org/10.1016/j.isci.2024.109323DOI Listing

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