Chylothorax is a lymphatic chylous pleural effusion typically associated with traumatic (iatrogenic, non-iatrogenic) and non-traumatic (infections, malignancy, lymphatic disorders) aetiologies. Drug-induced chylothorax is uncommon and mostly reported in association with tyrosine kinase inhibitor therapy.
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Drug-induced chylothorax as a rare pleural complication in dasatinib therapy for chronic myeloid leukaemia.
J R Coll Physicians Edinb
March 2024
Division of Respiratory and Critical Care Medicine, University Medicine Cluster, National University Health System, Singapore.
Chylothorax is a lymphatic chylous pleural effusion typically associated with traumatic (iatrogenic, non-iatrogenic) and non-traumatic (infections, malignancy, lymphatic disorders) aetiologies. Drug-induced chylothorax is uncommon and mostly reported in association with tyrosine kinase inhibitor therapy.
View Article and Find Full Text PDFDasatinib-associated chylothorax in a pediatric patient with chronic myeloid leukemia: a case report and literature review.
Transl Cancer Res
January 2023
Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
Background: Dasatinib is an effective 2 generation tyrosine kinase inhibitor for the treatment of newly diagnosed or intolerant to imatinib chronic myeloid leukemia (CML), and in Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). The most common adverse effects of dasatinib include gastrointestinal upset, pancytopenia, skin rash, diarrhea and fluid retention. Pleural effusion (PE), which occurs in almost 15-35% of patients, is the most frequent manifestation of fluid retention.
View Article and Find Full Text PDFDasatinib-induced chylothorax: report of a case and review of the literature.
Invest New Drugs
October 2020
Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, China.
Dasatinib is a tyrosine kinase inhibitor for the treatment of BCR-ABL-positive chronic myeloid leukaemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). Although fluid retention is a common adverse event associated with dasatinib, chylothorax is exceptionally rare. The pathological mechanism, clinical manifestation and management of dasatinib-induced chylothorax are completely unclear.
View Article and Find Full Text PDFMinocycline induced lupus with yellow colored chylous exudative pleural effusion.
Respir Med Case Rep
July 2017
Geriatrics Department, Kaplan Medical Center, Affiliated with The Hebrew University of Jerusalem, Israel, Rehovot, Israel.
Ninety years old male was admitted to hospital due to breathlessness. The prominent findings were extensive blue-grey skin pigmentation and large left chylothorax. Drug induced lupus was diagnosed due to either minocycline chronic treatment or no alternative illness to explain his sub-acute disease.
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